大理地区10岁以下白族儿童乙肝表面抗体调查

Investigation of Hepatitis B Surface Antibody of Bai Nationality Children aged below 10 Years Old in Dali Region

目的了解大理地区白族儿童乙肝免疫状况,探讨儿童乙肝加强免疫最适年龄。方法对该院就诊的2 958例10岁及以下儿童采用时间分辨荧光分析法进行抗-HBs检测,检测结果分别按年龄、性别分组与抗体定量水平高低进行分组统计分析。结果 2 958例白族儿童抗-HBs结果阳性(>10 m IU/m L)1 410例,占47.7%,其中高水平阳性(>100 m IU/m L)573例占19.4%,随着年龄的增加抗-HBs水平呈逐渐下降趋势;,3岁以下组588例中抗-HBs阳性459例占78.1%,其中高水平阳性234例占39.8%,3岁及以上组2 370例中抗-HBs阳性951例占40.1%,其中高水平阳性339例占14.3%,两组间差异有统计学意义(P<0.01)。男性1 794例中抗-HBs结果阳性857例,占47.8%,其中高水平阳性333例占18.6%,女性抗-HBs结果阳性(>10 m IU/m L)1 164例,占47.5%,其中高水平阳性240例,占20.6%,二者差异无统计学意义(P>0.05)。结论大理地区3岁以上组白族儿童对乙肝病毒免疫力明显低于3岁以下组,因此儿童进行乙肝疫苗加强免疫的最适合年龄为年满3岁左右。

Objective To investigate the hepatitis B immune status of children of Bai nationality in Dali area, and to explore the optimal age of hepatitis B immunization in children. Methods A total of 2 958 cases of children aged 10 years and below were examined by time- resolved fluoroscopy. The results were statistically analyzed by age, sex and antibody quantification.Results There were 1 410 cases（47.7%） of anti-HBs positive results in 2 958 children with anti-HBs（ 100 m IU/m L）, 573cases（19.4%）, anti-HBs with age of the 588 cases of anti-HBs positive in 459 cases accounted for 78.1%, of which a high level of positive 234 cases accounted for 39.8% of the total number of cases of 3 years of age,（951 cases） were anti-HBs positive in 2 370 cases（40.1%）. The positive rate of high-level positive expression in 339 cases（14.3%） was statistically significant（P〈0.01）. There were 857 cases（47.8%） of 1 794 cases of anti-HBs results in male, among which 333 cases of high-level positive cases（18.6%）, 1 164 cases of anti-HBs results（ 10 m IU/m L）（47.5%）, of which 240 cases of high level of positive accounted for 20.6%, the two were not statistically significant（P〈0.05）. Conclusion The immunity of hepatitis B virus in children of 3 years old or above in Dali area is obviously lower than that of children under 3 years old. Therefore,the most suitable age for strengthening hepatitis B vaccine is about 3 years old.