黄体酮阴道缓释凝胶在体外受精-胚胎移植黄体支持中的应用效果

Application effect of progesterone sustained-released vaginal gel for luteal phase support in vitro fertilization and embryo transfer

目的分析黄体酮阴道缓释凝胶在体外受精-胚胎移植(IVF-ET)黄体支持中的有效性和安全性。方法选择2015年1~12月于我中心接受长方案IVF-ET助孕患者992例,按照不同的黄体支持方案进行分组:黄体酮60 mg肌内注射组(A组)56例,黄体酮40 mg肌内注射组(B组)740例,黄体酮阴道缓释凝胶外用组(C组)196例。比较三组患者的妊娠率、种植率、多胎率、流产率和异位妊娠率及药物不良反应发生率。结果三组的妊娠率、种植率、多胎率、流产率、异位妊娠率比较,差异无统计学意义(P>0.05),但是C组妊娠率、多胎率、种植率有增高趋势,流产率有降低趋势。C组的药物总不良反应发生率明显低于A、B两组,差异有统计学意义(P<0.01)。结论黄体酮阴道缓释凝胶是有效、安全的IVF-ET黄体支持方法之一。

Objective To analyze the efficacy and safety of progesterone sustained-released vaginal gel for luteal phase support in vitro fertilization-embryo transfer（IVF-ET）.Methods From January to December 2015,992 patients who were agreed on long-term regimen of IVF-ET were selected.According to different progesterone-support regimens,they were divided into group A（muscular injection progesterone 60 mg,n=56）,group B（muscular injection progesterone 40 mg,n=740）,and group C（external application of progesterone sustained-released vaginal gel,n=196）.The pregnancy rate,implantation rate,multiple-gestation pregnancy rate,miscarriage rate,ectopic pregnancy rate and incidence of adverse drug reactions were compared among the three groups.Results There was no significant difference in pregnancy rate,implantation rate,multiple gestation pregnancy rate,miscarriage rate,orectopic pregnancy rate among the three groups（P〉0.05）.However,the pregnancy rate,multiple gestation pregnancy rate and implantation rate had increasing tendency,and miscarriage rate was in a decrease tendency in group C.The total incidence of adverse drug reactions was significantly lower than that in the group A and B,the difference was statistically significant（P〈0.01）.Conclusion Progesterone sustained-released vaginal gel is one of the effective and safe methods for luteal phase support in IVF-ET.