低分子肝素治疗新生儿败血症的效果

Effect of low molecular heparin in the treatment of neonatal septicemia

目的探讨低分子肝素治疗新生儿败血症的有效性。方法收集2015年3月~2016年7月我院58例新生儿败血症患儿,按照入院顺序分成观察组与对照组,每组29例,对照组患儿实施传统抗生素类药物治疗,观察组患儿在对照组的基础上予以低分子肝素治疗,对比两组患儿临床治疗效果及治疗前后降钙素原(PCT)、C反应蛋白(CRP)水平变化。结果观察组患儿总有效率为96.55%,高于对照组的86.21%,差异有统计学意义(P<0.05)。观察组治疗后PCT和CRP为(0.29±0.17)ng/L和(5.52±2.37)mg/L,明显低于治疗前的(5.65±2.18)ng/L和(22.70±5.29)mg/L(P<0.05);观察组治疗后PCT、CRP明显低于对照组,差异有统计学意义(P<0.05)。结论低分子肝素联合抗生素治疗新生儿败血症具有明显的临床效果,可明显改善PCT、CRP,临床应用价值较高。

Objective To investigate effectiveness of low molecular heparin in the treatment of neonatal sepsis.Methods58 cases of neonatal septicemia in our hospital from March 2015 to July 2016 were collected and divided into observation group and control group according to admission order,29 cases in each group.Patients in the control group were treated by traditional antibiotic treatment,patients in the observation group were treated with low molecular heparin on the basis of the control group,clinical therapeutic effect,changes of procalcitonin（PCT） and C reactive protein（CRP）levels before and after treatment between two groups were compared.Results Total effective rate in the observation group was 96.55%,higher than 86.21% in the control group,and the difference was statistically significant（P〈0.05）.PCT and CRP level after treatment in the observation group was（0.29±0.17） ng/L and（5.52±2.37） mg/L respectively,significantly lower than（5.65±2.18） ng/L and（22.70±5.29 mg/L before treatment（P〈0.05）;PCT and CRP level after treatment in the observation group was significantly lower than that in the control group,and the difference was statistically significant（P〈0.05）.Conclusion Low molecular heparin combined antibiotics in the treatment of neonatal sepsis has obvious clinical effect,can significantly improve procalcitonin and CRP level,which has high clinical value.