硝苯地平治疗先兆早产的效果观察

Effect observation of Nifedipine treating threatened premature labor

目的探讨硝苯地平治疗先兆早产的临床效果。方法选取2014年6月~2016年6月我院收治的80例先兆早产孕妇为研究对象,采用随机数字表法分为观察组和对照组,每组40例。观察组采用硝苯地平进行治疗,对照组采用硫酸镁进行治疗,比较两组的疗效和不良反应发生率。结果观察组的保胎成功率为77.5%,对照组为75.0%,两组比较差异无统计学意义(P>0.05);观察组的不良反应发生率为15.0%,明显低于对照组的40.0%(P<0.05)。观察组患者孕龄延长时间>48 h及延长时间>7 d的比率分别为30.0%、45.0%,对照组分别为27.5%、42.5%,两组的孕龄延长情况差异无统计学意义(P>0.05)。结论硝苯地平、硫酸镁治疗先兆早产的效果相近,但硝苯地平的不良反应少,对新生儿无不良影响,可作为治疗先兆早产的首选药物。

Objective To explore the clinical effect of Nifedipine treating threatened premature labor.Methods 80 pregnant women with threatened premature labor treated by our hospital from June 2014 to June 2016 were selected as research objects and they were divided into observation group （n=40） and control group （n=40） using the random number table method.The observation group was treated by Nifedipine,while the control group was treated by Magnesium Sulfate.The curative effect and the incidence rate of adverse reaction between two groups were compared.Results The success rate of tocolysis in the observation group was 77.5%,and it was 75.0% in the control group,and the two groups had no statistical difference （P〉0.05）.The incidence rate of adverse reaction in the observation group （15.0%） was significantly lower than that of the control group （40.0%） （P〈0.05）.The rate of extension time of gestational week〉48 h and〉7 d in the observation group was 30.0%,45.0% respectively,and it was 27.5%,42.5% respectively in the control group,and the difference between the two groups in the prolongation of the gestational age was not statistically significant （P〉0.05）. Conclusion The effect of Nifedipine and Magnesium Sulfate treating threatened premature laboris similar,but the adverse reaction is fewer for Nifedipine,and it has no adverse effects on the newborn：and in can be used as the choice drug treating threatened premature labor.