生命早期多不饱和脂肪酸摄入对儿童过敏性疾病的影响研究进展

Research advance on the influence of exposure to polyunsaturated fatty acid in early life on childhood allergic diseases

近年来国内外儿童过敏性疾病发病率不断上升,对儿童生活质量及社会经济效益造成巨大损害。儿童过敏性疾病不仅严重影响了儿童本身的身心健康,而且是成人期过敏性疾病的危险因素,因此对其进行防治具有重要的公共卫生意义。多项研究提示,生命早期多不饱和脂肪酸暴露是过敏性疾病发病的影响因素,但相关机制尚未充分阐明。此外,多不饱和脂肪酸的暴露剂量、时间点和持续时间等对过敏性疾病的作用尚不明确。本文对生命早期多不饱和脂肪酸摄入与儿童过敏性疾病关系的研究进展做一综述。

In the last few years,the incidence of allergic diseases has been rising constantly,which lead to huge damage to children＇s life quality and socio-economic benefits. The occurrence of allergic diseases in early life not only exerted negative influence on children＇s physical and mental health,but also might turn into a risk factor for allergic diseases in adulthood. Therefore,the prevention of allergic diseases in childhood is of great significance to the public health. There are evidence showing that the exposure of polyunsaturated fatty acid in early life can influence the development of allergic diseases. However,the related mechanisms have not been fully elucidated. The effect of different dose,timing and duration of exposure to polyunsaturated fatty acid on allergic diseases are still unclear. In this review,we would present the available information on the relationship of exposure to polyunsaturated fatty acid early in life and childhood allergic diseases and its related mechanisms.