妊娠期女性HPV感染基因型及临床治疗

Infected Genotype of HPV on Pregnant Women and Its Clinical Treatment

目的:调查分析笔者所在医院辖区范围内妊娠期女性人乳头瘤病毒(HPV)感染及基因型分布情况和特点,并探讨康复新液联合保妇康栓治疗妊娠期女性HPV的临床疗效。方法:随机选取2014年1月-2015年12月笔者所在医院门诊就诊的1456例妊娠期女性患者为观察组,观察组中372例HPV阳性者随机平均分为试验组和常规组(每组186),试验组康复新液联合保妇康栓治疗,常规组保妇康栓治疗;同期随机选取妇科门诊1077例非妊娠期女性为对照组。采用21种型HPV多重PCR荧光检测法对各组患者的子宫颈脱落细胞标本进行检测,并对各组患者的检测结果及治疗结果进行分析比较。结果:观察组中HPV阳性者25.5%(372/1456),其中HPV11 12.9%(188/1456),HPV16 4.1%(60/1456),HPV43 1.8%(26/1456),HPV33 1.4%(20/1456)和HPV58 1.3%(19/1456);对照组中HPV阳性者16.4%(177/1077),其中HPV11 8.0%(86/1077),HPV16 2.6%(28/1077),HPV431.1%(12/1077),HPV33 0.9%(10/1077)和HPV58 0.8%(9/1077);观察组总HPV感染阳性率及各高危HPV亚型均高于对照组,差异均有统计学意义(P<0.05)。治疗后,试验组治愈率及复发率均优于常规组,差异均有统计学意义(P<0.05)。结论:笔者所在医院辖区范围内妊娠期女性高危HPV亚型感染率比较高,且以高危型为主,可能与妊娠期女性长期处于免疫功能抑制状态有关,康复新液联合保妇康栓对宫颈HPV感染的治疗效果优于常规治疗方法。

Objective： To investigate pregnant female human papilloma virus（HPV） infection and genotype distribution and characteristics in the scope of the jurisdiction of our hospital, and to investigate the clinical efficacy of Kangfuxin combined with Baofu Kang in the treatment of pregnant women HPV. Method： From January 2014 to December 2015 in our hospital, 1456 cases outpatient of pregnant women was randomly selected as the observation group, 372 cases of HPV-pesitive in observation group were randomly divided into the experimental group（186 cases） and the conventional group（186 cases）. The experimental group used Kangfuxin eombind with Banfu Kang suppository treatment, the conventional group used Baofu Kang suppository.In the same period, 1077 cases of non-pregnant women in gynecology clinic were randomly selected as the control group.Cervical exfoliated cells samples were determined using 21 kinds of HPV type fluorescent multiplex PCR assay, and the test results and treatment results of patients in each group were analyzed and compared.Result： HPV-positive was 25.5%（372/1456） in the observation group, of which HPV11 12.9%（188/1456）, HPV16 4.1%（60/1456）, HPV43 1.8%（26/1456）, HPV33 1.4%（20/1456） and HPV58 1.3%（19/1456）; in the control group, 16.4%（177/1077） were positive for HPV, of which HPVll 8.0%（86/1077）, HPV16 2.6%（28/1077）i HPV43 1.1%（12/1077）, HPV33 0.9%（10/1077） and HPV58 0.8%（9/1077）.In the observation group, the total positive rate of HPV infection and high-risk HPV subtypes were higher than those of control group,the differences were statistically significant（P〈0.05）.After treatment, the cure rate and recurrence rate of the experimental group was better than the conventional group, the differences were statistically significant（P〈0.05）.Conclusion： Shenzhen pregnant women infected with high- risk HPV subtypes is relatively high, and mainly in high-risk, pregnant women may be related to long-term state of suppressed immune function, treatment of Kangfuxin combined with Baofu Kang is better than conventional treatment.