代谢综合征各组分与良性前列腺增生症的相关性研究

Relationship between the Components of Metabolic Syndrome and Benign Prostatic Hyperplasia

背景流行病学研究显示,代谢综合征(MS)与良性前列腺增生症(BPH)具有密切联系,MS可能是加剧BPH的危险因素,而且MS某些相关指标可能是BPH的预测因素。目的探讨MS各组分对BPH的影响,分析BPH疾病进展的可能危险因素,从而为临床防治BPH提供依据。方法选取2013年1月—2014年10月首都医科大学附属北京安贞医院泌尿外科收治的BPH合并MS患者214例为研究对象。记录患者年龄、吸烟史、饮酒史、体质指数(BMI),检测低密度脂蛋白胆固醇(LDL-C)、血尿酸、尿微量清蛋白水平。B超检测前列腺体积、膀胱残余尿量,采用尿流动力学分析仪检测最大尿流率,以国际前列腺症状评分(IPSS)评价患者下尿路症状严重程度。结果多元线性回归分析显示,年龄是BPH合并MS患者前列腺体积、膀胱残余尿量、最大尿流率、IPSS的影响因素(b=0.223、0.778、-0.151、0.116,P<0.01),LDL-C是BPH合并MS患者最大尿流率的影响因素(b=-0.441,P<0.01),尿微量清蛋白是BPH合并MS患者IPSS的影响因素(b=0.023,P<0.01)。结论 MS与BPH密切相关,LDL-C和尿微量清蛋白改变可能是MS、BPH的共同环节,可加剧BPH患者疾病发展。

Background Epidemiological studies has shown that metabolic syndrome（ MS） and benign prostatic hyperplasia（ BPH） were closely related.MS may be a risk factor for exacerbating BPH,and some indicators of MS may be predictive factors of BPH.Objective To explore the influence of each component of MS on BPH,analyze the possible risk factors of BPH progression,thus to provide basis for clinical prevention and treatment of BPH.Methods Two hundred and fourteen BPH patients combined with MS,who were admitted into Department of Urology of Beijing Anzhen Hospital,Capital Medical University from January 2013 to October 2014,were chosen as research objects.Age,history of smoke and alcohol,body mass index（ BMI） were recorded,and levels of low density lipoprotein cholesterol（ LDL-C）,blood uric acid,and microalbuminuria were detected.Prostate volume and residual urine volume in bladder were measured by B-ultrasound,maximal urinary flow rate were measured by urodynamics analyzer,severity of lower urinary tract symptoms were evaluated by International Prostate Symptom Score（ IPSS）.Results Multivariate linear regression analysis showed that age had significant effects on prostate volume,residual urine volume in bladder,maximal urinary flow rate,and IPSS（ b = 0.223,0.778,-0.151,0.116,P〈0.01）,LDL-C significantly affected maximal urinary flow rate（ b =-0.441,P〈0.01）,and microalbuminuria was the influencing factor for IPSS in BPH patients combined with MS（ b = 0.023,P〈0.01）.Conclusion MS and BPH are closely related,LDL-C and microalbuminuria may be the common feature of MS and MS,which exacerbates BPH development.