参附注射液联合无创正压通气治疗急性左心衰竭的效果观察

Shenfu injection combined with NPPV in treatment of rescue acute left ventricular failure

目的探讨参附注射液联合无创正压通气(NPPV)治疗急性左心衰竭(ALHF)的临床效果。方法将108例ALHF患者根据治疗方案不同分为两组,各54例。两组均给予常规抢救措施及NPPV治疗,在此基础上,对照组给予左西孟旦治疗,观察组给予参附注射液治疗。对比两组治疗前后左心室功能指标[左室射血分数(LVEF)、E峰/A峰比值(E/A比值)]及血气分析指标Pa O2、Pa CO2水平,并统计治疗效果。结果治疗前,两组患者LVEF、E/A比值及Pa O2、Pa CO2水平比较,差异均无统计学意义(P>0.05);经治疗,观察组LVEF、E/A比值及Pa O2高于对照组,Pa CO2低于对照组,且治疗总有效率94.44%,高于对照组的81.48%(P<0.05)。结论参附注射液联合NPPV治疗ALHF效果显著,可有效改善患者心功能及通气功能。

Objective To explore the clinical effect of Shenfu injection combined with noninvasive positive pressure ventilation（ NPPV） in the treatment of acute left heart failure（ ALHF）. Methods One hundred and eight patients with ALHF in our hospital were divided into two groups,according to the treatment regimen,54 patients in each group. Two groups were given conventional rescue measures and NPPV treatment,on this basis,the control group was treated with levosimendan,and the observation group was treated with Shenfu injection. The left ventricular ejection fraction（ LVEF）,E / A ratio（ E / A） were measured before and after the treatment. The Pa O2,Pa CO2 level,and clinical efficacy were compareed. Results There was no significant difference in LVEF,E / A,Pa O2 and Pa CO2 between the two groups（ P〉0.05）. After treatment,the LVEF,E / A and Pa O2 of the observation group were higher than those of the control group,Pa CO2 was lower than that of the control group,and the total effective rate of observation group（ 94. 44%） was higher than that of the control group（ 81. 48%）,which was statistically significant（ P〈0.05）. Conclusion Treatment of ALHF with Shenfu injection and NPPV can improve cardiac function and ventilatory function,the clinical effect is significant.