摘要
Human diseases may be caused by the malfunction of an intact protein.Hydrogen bond(h-bond)is one of the key interactions in maintaining the structure of a protein and facilitating its function.The presence and extent of h-bond cooperativity in proteins remains a fundamental question,and quantitative
Human diseases may be caused by the malfunction of an intact protein.Hydrogen bond（h-bond）is one of the key interactions in maintaining the structure of a protein and facilitating its function.The presence and extent of h-bond cooperativity in proteins remains a fundamental question,and quantitative analysis of h-bond cooperativity is still lacking.
