不同剂量激素治疗视神经炎临床疗效观察

Clinical Observation of Optic Neuritis Treated by Different Doses of Hormone

目的：探讨不同剂量地塞米松治疗急性视神经炎的临床疗效。方法：对2013年11月~2015年10月于我院接受治疗的90例视神经炎患者的临床资料进行回顾性分析,按照使用剂量的不同分为低剂量组（10 mg）和高剂量组（20 mg）。对比分析两组患者的治疗总有效率,治疗前和治疗后1、3个月的视力恢复情况以及眼部并发症发生情况。结果：与低剂量组患者相比,高剂量组患者治疗后3个月的视力恢复情况改善更为显著（P〈0.05）;高剂量组的治疗总有效率为88.9%,明显高于低剂量组的64.4%,差异有统计学意义（P〈0.05）;随访患者6个月,低剂量组眼部炎症的复发率高于高剂量组,而两组患者继发性青光眼和白内障的发生率比较差异无统计学意义（P〉0.05）。结论：大剂量地塞米松更有利于急性视神经炎患者视力的恢复,减少复发率,且不增加不良反应发生率,在临床上值得推广应用。

Objective： To investigate the clinical effect of optic neuritis treated by different doses of hormone. Methods： 90 Patients with optic neuritis in our hospital fxom November 2013 to October 2015 were divided into low dose group （10 mg） and high dose group （20 rag）. The total effective rate of two groups was compared and analyzed. The visual acuity and the occurrence of ocular complications were compared before and atier treatment, 1 months and 3 months later. Results： Compared with the low dose group, atler 3 months of recovery, the visual acuity of high dose group improved significantly （P〈0.05）; the total effective rate of high dose group was 88.9%, which was significantly higher than that of the low dose group, the difference was statistically significant （P〈0.05）. After 6 months＇ follow-up, the ocular inflammation recurrence rate of low dose group was higher than that of high dose group, and the glaucoma and cataract rate of two groups were no significant difference （P〉0.05）. Conclusion： High dose dexamethasone is more conducive to acute optic neuritis patients recovery, reduce the recurrence rate and without increasing the incidence of adverse reactions, it is worthy of clinical application.