胺碘酮、美托洛尔联合治疗慢性心力衰竭并发心律失常的效果分析

Analysis of effect by amiodarone combined with metoprolol in the treatment of chronic cardiac failure complicated with ventricular arrhythmias

目的探讨胺碘酮联合美托洛尔治疗慢性心力衰竭并发室性心律失常的临床效果。方法 74例慢性心力衰竭并发室性心律失常患者,随机分为单一组和联合组,各37例。单一组患者仅采用胺碘酮治疗,联合组患者采用胺碘酮联合美托洛尔治疗。比较两组临床疗效。结果联合组心功能改善总有效率为86.49%、心律失常改善总有效率为91.89%,均明显高于单一组的64.86%,72.97%,差异具有统计学意义(P<0.05);联合组再次住院率、心血管事件发生率均明显低于单一组,差异具有统计学意义(P<0.05);联合组药物不良反应发生率为8.11%,单一组为5.41%,两组比较差异无统计学意义(P>0.05)。结论胺碘酮联合美托洛尔治疗慢性心力衰竭并发室性心律失常疗效确切,且不良反应少,值得推广及应用。

Objective To investigate clinical effect by amiodarone combined with metoprolol in the treatment of chronic cardiac failure complicated with ventricular arrhythmias. Methods A total of 74 chronic cardiac failure complicated with ventricular arrhythmias patients were randomly divided into single group and combined group, with 37 cases in each group. The single group received singe amiodarone for treatment, and the combined group received amiodarone combined with metoprolol for treatment. Clinical effects were compared between the two groups. Results The combined group had total effective rate of cardiac function improvement as 86.49% and total effective rate of arrhythmia improvement as 91.89%, which were all higher than 64.86% and 72.97% in the single group, and their difference had statistical significance （P〈0.05）. The combined group had obviously lower re-hospitalization rate and incidence of cardiovascular event than the single group, and their difference had statistical significance （P〈0.05）. The combined group had incidence of adverse drug reactions as 8.11%, which was 5.41% in the single group, and the difference had no statistical significance between the two groups （P〉0.05）. Conclusion Combination of amiodarone and metoprolol provides precisely curative effect in treating chronic cardiac failure complicated with ventricular arrhythmias, along with few adverse reactions. It is worth promoting and applying.