甲状腺功能减退性肌病的临床特点

Clinical features of hypothyroid myopathy

目的了解甲状腺减退性肌病的临床特征,提高临床诊疗工作中对甲状腺功能减退性肌病的认识,减少误诊误治。方法回顾性分析我院近10年收治的11例甲状腺功能减退性肌病患者的临床特征、实验室检查及辅助检查,并复习相关文献了解其可能的病理生理机制。结果甲状腺功能减退性肌病临床表现复杂,实验室检查常合并血常规、肌酶及血脂异常,肌电图改变无明显特异性,甲状腺激素替代治疗有效。结论在神经内科诊疗工作中,对以肌无力、肌肉疼痛等肌病症状为主诉的患者,应完善TSH检查,减少甲状腺功能减退性肌病的误诊误治。

Objective To investigate the clinical features of hypothyroid myopathy, to increase the knowledge of hypothyroid myopathy in clinical diagnosis and treatment, and to reduce misdiagnosis and mistreatment. Methods A retrospective analysis was performed for the clinical features, laboratory examination, and auxiliary examination of 11 patients with hypothyroid myopathy who were admitted to our hospital within the past 10 years, and related articles were reviewed to investigate the possible pathophysiological mechanism of this disease. Results Hypothyroid myopathy had complex clinical manifestations. The patients with this disease often had abnormal results of routine blood test, muscle enzymes, and blood lipids, while there were no specific changes in electromyographic results. Thyroid hormone replacement therapy was effective in the treatment of this disease. Conclusions In the diagnosis and treatment of neurological diseases, thyroid stimulating hormone should be measured in patients with chief complaints of muscle weakness and muscle pain, in or- der to reduce the misdiagnosis and mistreatment of hypothyroid myopathy.