顺铂联合氟尿嘧啶化疗同步放疗治疗宫颈癌的近期疗效及毒副反应分析

Short-term efficacy and side effects of cisplatin combined with fluorouracil chemotherapy and concurrent radiotherapy in the treatment of cervical cancer

目的 探讨顺铂联合氟尿嘧啶化疗同步放疗治疗宫颈癌的近期疗效及毒副反应。方法 选择2010年2月-2013年2月我院接诊的80例宫颈癌患者的临床资料进行回顾性分析,所有患者均采用顺铂联合氟尿嘧啶治疗,按随机数表法分为两组,观察组患者40例,采用化疗同步放疗治疗,对照组患者40例,采用单纯放疗治疗,比较两组的近期、远期疗效及毒副反应情况。结果 观察组有效率为95.0%,对照组有效率为72.5%,观察组有效率明显高于对照组,差异有统计学意义（P〈0.05）;观察组的转移率7.5%,复发率5.0%,生存率97.5%,对照组转移率25.0%,复发率20.0%,生存率85.0%,观察组转移、复发和生存率均低于对照组,差异有统计学意义（P〈0.05）;观察组白细胞下降13例（32.5%）,血小板减少14例（35.0%）,恶心呕吐15例（37.5%）,肾功能受损3例（7.5%）,对照组白细胞下降5例（12.5%）,血小板减少6例（15.0%）,恶心呕吐4例（10.0%）,肾功能受损2例（5.0%）,观察组患者毒副反应与对照组比较明显更高,差异有统计学意义（P〈0.05）。结论 采用顺铂联合氟尿嘧啶化疗同步放疗治疗宫颈癌,能提高患者的近期和远期治疗疗效,毒副反应较高,毒副反应在可控范围内,有较高的临床价值。

Objective To investigate the short-term efficacy and side effects of cisplatin combined with fluorouracil and concurrent radiotherapy in the treatment of cervical cancer. Methods The clinical data of 80 patients with cervical can- cer admitted from February 2010 to February 2013 were retrospectively analyzed. All patients were treated with cis- platin combined with fluorouracil and divided into two groups according to the random number table. 40 patients in the observation group were treated with chemotherapy combined with radiotherapy, and 40 patients in the control group were treated with radiotherapy alone. And the short-term and long-term efficacy and toxicity of the two groups were compared. Results The effective rate was 95.0% in the observation group and 72.5% in the control group. The effective rate of the observation group was significantly higher than that of the control group（P〈0.05）. The metastasis rate, the recurrence rate and survival rate of the observation group was 7.5%, 5.0% and 97.5%, respectively, significantly lower than those of the control group （25.0%, 20.0% and 85.0%, P〈0.05）. There were 13 cases （32.5%） of leukopenia, 14 cases （35.0%） of thrombocytopenia, 15 cases（37.5%） of nausea and vomiting and 3 cases（7.5%） of renal dysfunction in the observation group. And in the control group, there were 5 cases（12.5%） of leukopenia, 6 cases（15.0%） of thrombocytopenia, 4 cases （10.0%） of nausea and vomiting and 2 cases （5.0%） of renal dysfunction. The toxicity of the observation group was significantly higher than that of the control group（P〈0.05）. Conclusion Cisplatin combined with fluorouraeil chemotherapy and eoncerrent radiotherapy for cervical cancer can improve the short-term and long-term therapeutic effect of patients, and the high toxic and side effects are in the controllable range, with high clinical value.