血清ADAMTSL-1蛋白检测在慢性肝病中的临床价值初探

Exploration of clinical value of serum ADAMTSL-1 detection in chronic liver diseases

目的 探讨血清ADAMTSL-1蛋白检测在慢性肝病中的临床意义。方法 收集2016年2-4月在宁波市第二医院肝病中心就诊的80例慢性肝病患者作为实验组,根据Child-Pugh评分分为A级32例,B级30例,C级18例,另外选择24例健康体检者作为正常对照组。检测各组人群血清中的ADAMTSL-1蛋白浓度,并进行统计学分析。结果 慢性肝病患者的血清ADAMTSL-1蛋白浓度为10.93（9.43-16.36）ng/m L,显著高于正常对照组的7.53（6.91-8.17）ng/m L（t=5.47,P〈0.01）;慢性肝病患者血清ADAMTSL-1蛋白浓度随着Child-Pugh评分的升高而增加（F=12.33,P〈0.01）。结论 血清ADAMTSL-1蛋白有可能成为反映慢性肝病患者肝脏储备功能的新指标。

Objective To investigate the clinical significance of serum ADAMTSL-1 in chronic liver disease. Methods 80 cases of patients with chronic liver disease admitted to Liver Disease Center in Ningbo No.2 Hospital from February to April 2016 were collected as the experimental group. There were 32 cases of grade A, 30 cases of grade B and 18 cases of grade C according to the Child-Pugh score. In addition, 24 healthy subjects were selected as normal control group. The serum concentration of ADAMTSL-1 protein in each group was detected and analyzed statistically. Results The serum ADAMTSL-1 protein concentration in patients with chronic liver disease was 10.93（9.43-16.36） ng/mL, which was significantly higher than 7.53（6.91-8.17） ng/mL in the control group（t=5.47, P〈0.01）. The serum ADAMT- SL-I protein eoncentration increased with the Child-Pugh score in chronic liver disease patients（F=12.33, P〈0.01）. Conclusion Serum ADAMTSL-1 protein may be a new indicator of hepatic reserve function in patients with chronic liver disease.