角蛋白17与银屑病

Keratin 17 and psoriasis

角蛋白17作为一种细胞骨架蛋白,在银屑病患者皮损中过度表达,被认为是银屑病的一种特异性标志物。角蛋白17是一种自身抗原,携带某些和链球菌M6蛋白相似的表位。这些表位可以刺激自身反应性T细胞增殖,促进银屑病相关的细胞因子释放,继而进一步刺激角质形成细胞产生角蛋白17。研究表明角蛋白17/T细胞/细胞因子自身免疫环路可能参与银屑病的发病机制,角蛋白17有可能成为一种新的银屑病治疗靶点。

As a cytoskeletal protein, keratinl7 （K17） is over-expressed in psoriatic lesional epidermis, and is considered to be a hallmark of psoriasis.K17 is an autoantigen with certain epitopes similar to M6 protein of streptococci. These epitopes can stimulate the proliferation of autoreactive T cells and promote the release of psoriasis-related cytokines which stimulate keratinocyte to induce K17. Some studies indicate that K17/T cells/cytokine autoimmune loops may be present in the pathogenesis of psoriasis. K17 may be an attractive target of the novel therapies in psoriasis.