摘要
DNA甲基化是重要的表观遗传学修饰，与基因表达异常、DNA损伤修复、基因组不稳定性，遗传性状的改变密切相关。以往的研究已经证实许多肿瘤的发生与DNA甲基化调控相关，最近有不少报道表明在慢性病[如肥胖，糖尿病，心脑血管疾病，哮喘，慢性阻塞性肺疾病（COPD）等]发生发展过程中，一些特异性基因启动子区域CpG岛甲基化发生了改变，可能是导致慢性病发病的主要因素。文章阐述了DNA甲基化水平在一些慢性病发生、发展过程中的变化及其影响，为相关疾病的预防、诊断以及治疗提供新的思路。
DNA methylation is an important with the abnormal expression of genes, DNA epigenetic modification and it is closely associated damage repair, genomic instability, and changes of some genetic traits. Previous studies have confirmed that DNA methylation regulation is involved in the development of many tumors. Recently, studies found that CpG island methylation in some specific gene promoter region changed in some chronic diseases, such as obesity, diabetes mellitus, cardiovascular and cerebrovascular diseases, asthma and chronic obstructive pulmonary disease, suggesting DNA methylation is responsible for these chronic diseases. This review describes the changes of DNA methylation in the occurrence and development of some chronic diseases and their effects on these diseases, and provides a new idea for the prevention, diagnosis and treatment of related diseases.
作者
段鹏
张昉
雷毅雄
杨萍
DUAN Peng ZHANG Fang LEI Yixiong YANG Ping(Guangzhou Medical University, Guangzhou, 510182, China)
出处
《医学分子生物学杂志》
CAS
2017年第1期26-29,共4页
Journal of Medical Molecular Biology
基金
国家自然科学基金青年项目（No.81402716）,国家自然科学基金面上项目（No.81573177）,广州市科技计划项目（No.201510010109）
关键词
DNA甲基化
慢性病
肥胖
糖尿病
心血管疾病
哮喘
DNA methylation
chronic diseases
obesity
diabetes mellitus
cardiovascular disease
asthma
