CD4^＋T细胞亚群在类风湿关节炎中的研究

Role of CD4^＋T Cell Subsets in Rheumatoid Arthritis

类风湿关节炎（rheumatoid arthritis，RA）是由多因素共同作用引起的自身免疫性疾病，至今发病机制仍未完全阐明，CD4^＋T细胞在RA的发生发展中发挥重要作用。早期发现Th1／Th2细胞后，新的CD4^＋T细胞亚群不断被发现，包括Th17细胞、Treg细胞、Th22细胞、Th9细胞和Tfh细胞。不同CD4^＋T细胞亚群在RA中表达异常，深入研究不同亚群CD4^＋T细胞在RA中的作用可为RA的发病机制提供线索。

Rheumatoid arthritis （RA） is an autoimmune disease caused by multiple factors, and its pathogenesis has not yet been fully elucidated. CD4^＋T cells are demonstrated to play an important role in the development of RA. New CD4^＋T cell subsets, including Th17, Treg, Th22 cells, Th9 and Tfh cells, have been continuously found following the discovery of Th1/Th2 cells. They are abnormally expressed in RA. Further studying the role of CD4^＋T cell subsets in RA may provide clues for the pathogenesis of this condition.