卡前列素氨丁三醇与米索前列醇防治宫缩乏力性产后出血的效果比较

The Effect Comparison of Carboprost Tromethamine and Misoprostol for Prevention of Postpartum Hemorrhage Caused by Uterine Inertia

目的比较卡前列素氨丁三醇与米索前列醇防治宫缩乏力性产后出血的效果及不良反应。方法 70例宫缩乏力性产后出血高危因素的产妇根据数字表法随机分为2组,A组(n=35例)采用米索前列醇防治宫缩乏力性产后出血,B组(n=35例)采用卡前列素氨丁三醇防治宫缩乏力性产后出血。比较两组临床疗效、产后出血发生率、产后2 h和24 h出血量、第三产程时间、血红蛋白下降值及不良反应发生率。结果 B组治疗总有效率(94.29%)明显高于A组(77.14%)(P<0.05);B组产后2 h出血量、产后24 h出血量明显少于A组(P<0.05),第三产程时间明显快于A组(P<0.05),产后出血发生率和血红蛋白下降值明显高于A组(P<0.05);两组治疗期间均未出现严重不良反应,A组不良反应发生率(20.0%)与B组(14.29%)比较,差异无统计学意义(P>0.05)。结论卡前列素氨丁三醇防治宫缩乏力性产后出血的效果优于米索前列醇,可明显降低产后出血率。

OBJECTIVE To compare the effect and adverse reaction of carboprost tromethamine and misoprostol for prevention of postpartum hemorrhage caused by uterine inertia. METHODS 70 cases with high risk factors of postpartum hemorrhage maternal were randomly divided into 2 groups,A group（ n = 35 cases） was used with misoprostol in prevention of postpartum hemorrhage caused by uterine inertia,B group（ n = 35 cases） was used with carboprost tromethamine. The clinical efficacy,the incidence of postpartum hemorrhage,the amount of 2 h and 24 h,the third labor time,the decrease of hemoglobin and the incidence of adverse reaction of two groups were compared. RESULTS The total effective rate of B group（ 94. 29%） was significantly higher than that of A group（ 77.14%）（ P〈0.05）. The 2 h postpartum hemorrhage,24 h postpartum hemorrhage of B group was obviously less than that of A group（ P〈0.05）,the third labor time was significantly faster than that of group A（ P〈0.05）,and the incidence of postpartum hemorrhage and decrease in hemoglobin significantly higher than that of A group（ P〈0.05）. There were no serious adverse reaction in two groups during the treatment,the incidence of adverse reactions in group A（ 20. 0%） and B group（ 14. 29%） showed no significant difference（ P〈0.05）. CONCLUSION The effect of carboprost tromethamine for prevention of postpartum hemorrhage is better than misoprostol,can significantly reduce the rate of postpartum hemorrhage.