79例奥沙利铂相关不良反应分析

Analysis of 79 Cases of Oxaliplatin Adverse Reactions

目的探讨奥沙利铂(L-OHP)不良反应的发生特点,为临床合理用药提供参考。方法收集我院2005~2016年上报的关于L-OHP不良反应报告并进行相关文献复习。结果共收集到L-OHP相关不良反应报告79例,不良反应发生时间主要在3~120 min之间,中位周期为第6周期,中位累积剂量为557.6 mg/m^2,不良反应大都以过敏反应和神经毒性为主,Ⅲ级以上的不良反应报告有7例。结论 L-OHP的不良反应呈现剂量累积性,治疗前适当的预处理措施以及用药宣教可以降低奥沙利铂不良反应的发生率。

OBJECTIVE To discuss the characteristics of occurrence of ADRs induced by oxaliplatin（ L-OHP）,and to provide information for rational clinical use of the drug. METHODS ADR reports of L-OHP were collected from 2005- 2016 and related literatures were reviewed. RESULTS Among the 79 ADR reports collected,ADRs mainly occurred in 3-120 min after injection. The median chemotherapy period was the sixth cycle with a median cumulative dose 557.6 mg / m^2. Allergy and neurotoxicity were the major performances. 7 cases of severe adverse reaction were reported. CONCLUSION The ADRs of L-OHP appeared to correlate with the cumulative dose. Proper preparative regimens before treatment and medication education may reduce the incidence of ADR caused by LOHP.