摘要
目的探讨选择性5-羟色胺再摄取抑制剂(SSRIs)类药物治疗脑卒中后抑郁(PSD)的有效性和安全性。方法将符合标准的186例脑卒中后抑郁患者根据用药情况分为氟西汀、帕罗西汀、舍曲林、氟伏沙明、西酞普兰5组,用汉密尔顿抑郁量表(HAMD)和副反应量表(TESS)对治疗前后的情况进行比较分析。结果西酞普兰与舍曲林在治疗第2周即可见疗效。治疗4周后,各组HAMD与治疗前比较,差异有统计学意义(P<0.05),各组间疗效比较,差异无统计学意义(P>0.05)。TESS评分比较,西酞普兰的不良反应和副作用明显少于其他4组,差异有统计学意义(P<0.05)。结论卒中后抑郁选择SSRIs类药物治疗时,西酞普兰由于有较好的抗抑郁作用,且不良反应较少,可以作为治疗脑卒中后抑郁的第一选择。
OBJECTIVE To study the difference in therapeutic effects and side effects of SSRIs in treating Post-stroke Depression( PSD). METHODS 186 cases of PSD patients were divided into Fluoxetine,Paroxetine,Sertraline,Fluvoxamine,Citalopram group,then the patients were tested with Hamilton depression scale( HAMD) and Treatment Emergent Symtom Scale( TESS) before treatment and at the end of the second weekend,the forth weekend and the eighth weekend. RESULTS There were significant differences with HAMD between before and after the treatment of all of the SSRIs after 4 weeks( P〈0. 05),but there was no difference in five groups( P〈0.05).TESS showed Citalopram had less side effects than other SSRIs( P〈0.05). CONCLUSION Citalopram has the effect of anti-depression and little severity adverse effect,so it can be a effective and safe drug to treat post-stroke depression.
作者
杨葵香
翁汉育
林淑芳
张云周
刘通好
李杰红
李锐茹
YANG Kuixiang WENG Hanyu LIN Shufang ZHANG Yunzhou LIU Tonghao LI Jiehong LI Ruiru(Tangxia hospital, Dongguan, Guangdong 523721, China Dongguan People's Hospital, Dangguan, Guangdong 523000, China)
出处
《今日药学》
CAS
2017年第1期62-65,共4页
Pharmacy Today