餐后序贯与非序贯四联方案根除幽门螺杆菌临床疗效研究

目的观察比较餐后序贯与非序贯四联方案根除幽门螺杆菌（Hp）的临床疗效。方法确诊Hp阳性患者198例，随机分为餐后序贯及非序贯四联方案根除Hp，以胃镜病理组织学组织学免疫组化染色和14C-尿素呼气试验（UBT）进行根除评估。结果餐后序贯较非序贯四联方案能更有效根除Hp（P〈O．05），非序贯方案纽治疗失败者给予餐后序贯疗法补救也拥有较高根除率。结论餐后序贯四联方案根除幽门螺杆菌治疗效果较非序贯四联方案较好，值得临床推广应用。

Objective To compare the clinical effects of post-meal sequential therapy for eradicating Helicobacter pylori with non- sequential therapy, provide solution for effective according to Helicobacter pylori. Methods The patients who were diagnosed with helicobacter pylori infection from January 2014 - December 2015 were enrolled in this study, who were randomly divided into post-meal sequential group and non sequential group, with gastroscope pathological histology histologic, immunohistochemical staining and 14 c - urea breath test to evaluate eradication rate method. Results Post-meal sequential is more effective than non-sequential with the eradication of helicobacter pylori （ P〈0.05 ） , and ss one of the remedy, The Hp eradication rate was relatively high once again in failure cases receiving with non-sequential therapy. Conclusion The rate of helicobaeter pylori eradication is better in post-meal sequential quadruple therapythan non-sequential quadruple therapy, It is worthy of further popularization and application in clinical diagnosis and treatment.