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多发性骨髓瘤患者血清LDH β2-MG水平测定的临床意义 被引量:5

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摘要 目的:探讨分析多发性骨髓瘤患者血清LDH和β2-MG水平测定的临床意义。方法多发性骨髓瘤患者25例,健康体检者20例,检测并比较两组血清乳酸脱氢酶(LDH)和血清β2微球蛋白(β2-MG)水平。结果与对照组比较,多发性骨髓瘤Ⅰ期、Ⅱ期、Ⅲ期患者的血清LDH和β2-MG水平明显高于对照组,其中骨髓瘤Ⅲ期患者的β2-MG水平、血清LDH水平明显高于骨髓瘤Ⅰ期、Ⅱ期;骨髓瘤组治疗期间的血清LDH和β2-MG水平比较中,部分缓解组、有效组与无效组比较,差异有统计学意义(P〈0.05)。结论血清LDH和β2-MG水平检测为多发性骨髓瘤患者的病理分期、预后判断等提供重要的参考价值,可以作为临床诊断评估的辅助指标。 ObjectiveTo investigate the clinical significance of determination of multiple myeloma patients serum LDH and beta 2-MG level.Methods25 cases of multiple myeloma patients,20 healthy subjects,and detection of serum lactic acid were compared between the two groups(LDH)dehydrogenase and serum beta 2 microglobulin(beta 2-MG)results and level. Compared to the control group,multiple myeloma stage Ⅰ,Ⅱ,Ⅲ patients with serum LDH and beta 2-MG level was significantly higher than the control group,the bone marrow of patients with tumor stage Ⅲ beta 2-MG level,serum LDH level was significantly higher than that of myeloma stage I,II;during the myeloma group serum LDH and the level of 3 2-MG,partial remission group group,effective group and ineffective,the difference was statistically significant(P〈0.05).ConclusionsThe detection of serum LDH and beta 2-MG level in patients is valuable for clinical diagnosis, stagingand prognosis prediction for multiple myeloma.
作者 易莉娜
出处 《浙江临床医学》 2017年第1期136-137,共2页 Zhejiang Clinical Medical Journal
关键词 多发性骨髓瘤 血清LDH 血清Β2-MG 临床意义 Multiple myeloma Serum LDH Serum beta 2-MG Clinical significance
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