布地奈德悬液雾化治疗急性发作性支气管哮喘的疗效及对血清炎性因子的影响

Efficacy of Budesonide Suspension Inhalation in Treatment of Acute Attack of Bronchial Asthma and Effects on Inflammatory Factors

目的:探讨布地奈德悬液雾化治疗急性发作性支气管哮喘的疗效及对血清炎性因子白细胞介素(IL)及肿瘤坏死因子α(TNF-α)的影响。方法:选取2015年1月—2016年1月湖北省公安县人民医院呼吸内科收治的支气管哮喘急性发作期患者78例,按随机数字表法分为对照组与观察组,每组各39例。对照组患者给予常规药物治疗,观察组患者在对照组基础上联合应用布地奈德悬液雾化治疗。治疗结束后,比较2组患者肺功能、血清炎性因子水平变化情况。结果:治疗后,2组患者肺功能均较治疗前明显改善,且观察组患者改善情况明显优于对照组,差异均有统计学意义(P<0.05)。治疗后,2组患者血清炎性因子IL-4、IL-5、IL-6、IL-8、IL-13、IL-25、TNF-α水平均较治疗前降低,IL-2、IL-12、INF-γ水平均较治疗前升高,且观察组患者各指标改善情况均明显优于对照组,差异均有统计学意义(P<0.05)。结论:布地奈德悬液雾化治疗急性发作性支气管哮喘,可明显改善患者肺功能,减轻炎症反应,通过调节免疫而治疗支气管哮喘。

OBJECTIVE： To probe into the efficacy of budesonide suspension inhalation in treatment of acute attack of bronchial asthma and effects on inflammatory factors as IL and TNF-α. METHODS： 78 patients with acute attack of bronchial asthma admitted into Hubei Gong＇an County People＇s Hospital from Jan. 2015 to Jan. 2016 were selected to be divided into observation group and control group via the random number table,with 39 cases in each. The control group were treated with conventional medicine, while the observation group were given budesonide suspension inhalation based on the control group. After treatment,the lung function,changes of level of inflammatory factors of two groups were compared. RESULTS： After treatment,the lung function of two groups were significantly improved compared with before treatment,and observation group was better than that of control group,with statistically significant difference（ P〈0. 05）. After treatment,the level of IL-4,IL-5,IL-6,IL-8,IL-13,IL-25,TNF-α of two groups decreased significantly compared with before treatment,and observation group was better than that of control group,with statistically significant difference（ P〈0. 05）. CONCLUSIONS： Budesonide suspension inhalation in treatment of acute attack of bronchial asthma can effectively improve patients＇ lung function,reduce inflammatory reactions and effectively in treatment of bronchial asthma through regulation of the immune.