124例药物性肝损伤住院患者保肝药应用调查与分析

Investigation and Analysis on Application of Hepatoprotective Drugs in 124 Inpatients with Drug-induced Liver Injury

目的:了解西南医科大学附属医院药物性肝损伤住院患者保肝药的临床使用情况,为合理使用保肝药提供依据。方法:查阅该院2015年7月—2016年7月124例因药物性肝损伤住院的患者病历,对保肝药临床应用的适应证、药品选择、剂量、溶剂和联合用药等进行系统的回顾性调查分析。结果:中老年(≥45岁)是药物性肝损伤的高发年龄,共90例,占72.58%;引起肝功能损伤的药物种类较多;患者的临床表现中,乏力最多见;药物性肝损伤以肝细胞损伤型为主;临床保肝药的不合理应用较为明显,尤其体现在剂量不合理和重复给药等方面。结论:临床用药时,应从药物的疗效、不良反应等方面综合考虑,同时结合患者的具体情况,制订个体化治疗方案,合理使用保肝药。

OBJECTIVE： To investigate the clinical application status of hepatoprotective drugs in inpatients with drug-induced liver injury in the Affiliated Hospital of Southwest Medical University,so as to provide reference for the rational application of hepatoprotective drugs. METHODS： 124 inpatients with drug-induced liver injury were collected from this hospital from Jul. 2015 to Jul. 2016; retrospective analysis was conducted on the indications,drugs selection,dosage,solvent and drug combination. RESULTS： The middle-aged inpatients（ ≥45 years old） belonged to the high risk group of drug-induced liver injury,totally 90 cases,and accounted for 72. 58%. The categories of drugs that induced liver injury were various. Of the clinical manifestations,weakness was the most common one. Hepatocyte injury was the main type of drug-induced liver injury. Irrational application of drugs were obvious,especially irrational dosage and repeated administration. CONCLUSIONS： To promote rational drug use,it is necessary to consider the efficacy and adverse drug reactions of drugs in the clinical treatment,and to make plan for individualized treatment combined with the specific situation.