12例静脉滴注甘露聚糖肽致不良反应报告

12 Cases of Adverse Drug Reaction Reports Induced by Mannatide in Intravenous Drip

目的:了解静脉滴注甘露聚糖肽发生不良反应的情况,探讨其不良反应发生的规律及临床表现,为临床合理用药、防范不良反应提供参考。方法:对2012年3月—2016年6月河南理工大学第一附属医院/焦作市第二人民医院临床药学室收集上报的12例静脉滴注甘露聚糖肽致不良反应报告进行回顾性调查分析。结果:甘露聚糖肽致不良反应多在用药后30 min内发生;主要表现为过敏反应和呼吸系统损害;严重的不良反应主要为过敏性休克和哮喘。结论:静脉滴注甘露聚糖肽可引起严重不良反应,用药过程中医护人员应严密观察,一旦发生不良反应,应及时抢救处理。

OBJECTIVE： To investigate the adverse drug reactions（ ADR） induced by mannatide in intravenous drip,and to probe into the regularity and clinical manifestations of ADR,so as to provide reference for the rational drug use and avoid ADR in clinic. METHODS： Retrospective analysis was conducted on 12 cases of ADR induced by mannatide in intravenous drip collected by the First Affiliated Hospital of Henan Polytechnic University / Jiaozuo the Second People＇s Hospital（ hereinafter referred to as ＂our hospital＂） from Mar. 2012 to Jun. 2016. RESULTS： ADR mainly occurred within 30 min after mannatide injection,performed as allergic reactions and respiratory system disorders. Sever ADR were performed as allergic shock and asthma. CONCLUSIONS： Mmannatide in intravenous drip can induce severe ADR,which should be paid close attention during application. Effective rescue measures should be given in time when ADR appears.