椎管宁对无先兆偏头痛发作期镇痛的疗效观察

Observation on Analgesic Effect of Zhuiguanning on Migraine without Aura in Onset Period

目的观察椎管宁对无先兆偏头痛发作期镇痛的疗效。方法将68例无先兆偏头痛患者随机分为治疗组和对照组,各34例。治疗组服用椎管宁丸,对照组服用利扎曲普坦,2 h后疼痛未缓解上述剂量药物再服用1次。结果两组患者治疗2 h后头痛缓解50%的人数比治疗组优于对照组(P<0.05),两组在治疗后2 h、4 h头痛消失人数比均差异无统计学意义(P>0.05);两组患者治疗后即刻、30 min、2 h、4 h的视觉模拟量表(VAS)评分差异无统计学意义(P>0.05)。结论椎管宁对无先兆偏头痛发作期镇痛效果确切,而且总体疗效优于利扎曲普坦。

Objective： To observe the analgesic effect of Zhuiguanning on migraine without aura in onset period.Methods： 68 cases with MOA were randomly divided into the treatment group and the control group,34 cases in each. The treatment group took Zhuiguanning,while the control group took Rizatriptan. If the pain did not relieve after 2 hours,the drugs were taken once again. Results： After 2 hours,the treatment group was superior to the control group in the number of patients with 50% of headache relief. 2 hours and 4 hours after treatment,there was no significant difference in the number of patients with headache disappear between the two groups（P〉 0.05）;there was no significant difference in VAS scores right after treatment and 30 min,2 hours and 4 hours after treatment. Conclusion： Zhuiguanning has an exact analgesic effect on migraine without aura in onset period,and the overall effect is better than Rizatriptan.