促红细胞生成素联合养血益肾方在血液透析32例中的应用

Effect of Yangxue Yishen Decoction on Hepcidin and Ferroproteinin Hemodialysis Patients

目的:观察养血益肾方对血液透析贫血患者的临床疗效。方法:将维持性血液透析贫血患者91例分为促红素组(E组)30例、养血益肾组(Y组)29例和强化组(E+Y组)32例,分别给予促红素、养血益肾方和促红素联合养血益肾方治疗8周,比较治疗前后各组的铁调素(Hepcidin)、血红蛋白(HGB)、铁蛋白(SF)。结果:E+Y组Hepcidin、HCT、HGB、SF等指标的改善优于E组和Y组(P<0.05),E组对Hepcidin和SF的改善优于Y组(P<0.05),而Y组对HCT和HGB的改善与E组无统计学差异(P>0.05)。结论:养血益肾方对血液透析贫血患者具有纠正贫血的作用,可能与其在一定程度上降低Hepcidin,提高SF有关,但更与直接提高HCT和HGB关系更密切。

Objective To observe the clinical effect of Yangxue Yishen Decoction on hemodialysis patients with anemia. Methods 91 cases of maintenance hemodialysis patients with anemia were randomly divided into erythropoietin group （E group） 30 cases, Yan- gxue Yishen Decoction group （Y group） 29 cases and intensive group （E ＋Y group） 32 cases, which were given erythropoietin essence, Yangxue Yishen Decoction, Yangxue Yishen Decoction and erythropoietin for 8 weeks. Iron regulated hormone （hepcidin）, hemoglobin （Hgb） and ferritin （SF） each group were compared before and after being treated. ResultsThe improvement of Hepcidin, HCT, HGB, SF of E ＋ Y group were better than those of E group and Y group （ P 〈 0.05 ） . The improvement of SF and Hepcidin in E group was better than Y group （ P 〈 0. 05 ）, while the improvement of HCT and HGB in Y group was better than E group （ P 〈 0.05 ） . Conclusion Mechanism of Yangxue Yishen Decoction correcting anemia in patients with hemodialysis may be related to decreasing hepcidin and improving the SF some extent, but improving HCT and HGB directly more closely.