体外膜肺氧合对抗菌药物药代动力学影响的研究进展

Research advance in the effect of extracorporeal membrane oxygenation on the pharmacokinetics of antibacterials

体外膜肺氧合(ECMO)是用体外循环技术进行生命支持的一种有效的辅助手段。然而体外膜肺氧合会对患者同期治疗所使用的抗菌药物药代动力学产生影响,导致血药浓度的改变而影响药物治疗效果。本文根据现有证据对重症患者接受体外膜肺氧合治疗期间体内抗菌药物药代动力学的改变及其相关机制进行阐述,为优化体外膜肺氧合治疗期间的抗菌药物治疗方案提供一定的理论基础。

Extracorporeal membrane oxygenation（ ECMO） is an effective assistant method for the life support on the base of the extracorporeal circulation. ECMO will have an impact on the pharmacokinetics of antibacterials,which changing the plasma concentration of antibacterials in order to affect drug effects. To provide a theoretical basis for the optimization of antibacterial therapy regimens during ECMO treatment,this article described the changes of the pharmacokinetics of antibacterials in critically ill patients receiving ECMO treatment according to the published papers,as well as the correlated mechanism.