生物胶联合OK-432及博莱霉素治疗颌面部软组织动静脉畸形13例临床分析

Percutaneous sclerotherapy of arteriovenous malformations of the maxillofacial soft tissues using fibrin glue combined with OK-432 and bleomycin following embolization in 13 consecutive patients

目的 :评价生物胶联合OK-432及博莱霉素治疗颌面部软组织动静脉畸形(arteriovenous malformations,AVMs)的临床疗效。方法:13例颌面部软组织AVMs患者,男8例,女5例,平均年龄28.2岁。在超选择性血管内栓塞基础上,通过经皮注射生物胶联合OK-432及博莱霉素3~5次进行硬化治疗。结果:除术区1周内肿胀外,均无严重并发症出现。随访14~58个月(平均27.4个月),3例治愈,8例显效,2例有效,无无效病例。结论:生物胶联合OK-432及博莱霉素经皮硬化治疗术治疗颌面部软组织AVMs效果良好,方法简单、安全、可靠。

PURPOSE： To evaluate the clinical curative effect of percutaneous sclerotherapy of arteriovenous malformations（AVMs） of soft tissues of the maxillofacial region using fibrin glue combined with OK-432 and bleomycin.METHODS： Thirteen patients with AVMs of the maxillofacial region（8 males and 5 females; mean age： 28.2 years,range： 16-46 years） were treated with a percutaneous injection of fibrin glue combined with OK-432 and bleomycin for 3-5 times following super-selective intra-arterial embolization（SIAE）. RESULTS： All patients had significant swelling postoperatively for up to 1 week without major complications. The follow-up period ranged from 14-58 months（mean：27.4 months）. Three lesions were completely involuted, eight lesions were mostly involuted, and other two lesions were partially involuted. None of the lesions showed minimal involution or non-involution. CONCLUSIONS： Percutaneous sclerotherapy using fibrin glue combined with OK-432 and bleomycin following SIAE provides a simple, safe, and reliable alternative treatment for AVMs of soft tissues of maxillofacial region.