经皮肺穿刺注药治疗耐多药空洞型肺结核疗效的Meta分析

Efficacy of percutaneous lung cavity injection of medicine for treatment of multi-drug resistant cavernous tubercuiosis：a meta-analysis

目的 系统评价经皮肺穿刺注药治疗耐多药空洞型肺结核的疗效。方法 计算机检索Pubmed 、 CochranelLibrary 、 CKNI 、 CMB 、 Wanfangdatabase 、 VIP 数据库有关经皮肺穿刺注药治疗耐多药空洞型肺结核疗效的临床随机对照试验 （randomizedcontrolledtrial , RCT ）,检索时间从建库至 2016 年 4 月。由两名研究员按照纳入及排除标准进行文献筛选、资料提取和文献质量评价,应用RevMan5.3 软件进行 Meta 分析。结果 共纳入 15 个随机对照试验,涉及 1456 例耐多药空洞型肺结核患者。结果显示,经皮肺穿刺注药治疗耐多药空洞型肺结核的痰菌转阴率、空洞闭合率、病灶吸收率均明显高于单纯全身化疗组。结论 经皮肺穿刺注药可显著提高耐多药空洞型肺结核疗效,值得临床进一步研究及推广。

Objective To systematically review the efficacy of percutaneous lung cavity injection of medicine for treatment of multi-drug resistant cavernous tuberculosis. Methods The Pubmed,Cochranel Library,CNKI. CMB, VIP, Wanfang database were retrieved to collect the randomized controlled trial （RCT） of the efficacy of percutaneous lung cavity injection of medicine for treatment of multi-drug resistant cavernous tuberculosis, up to April 2016 sincedatabase establishment. Two reviewers in dependently screened studies according to the inclusion and exclusion criteria, extracted data and assessed quality of the included studies. Then Meta-analysis was conducted using RevMan 5.3 software. Results 15 RCT were included, involving 1 546 cases of multi-drug resistant cavernous tuberculosis. In the effectiveness, sputum negative conversion rate, cavity closure rate, lesion absorption rate with Percutaneous lung cavity injection were all higher than those in the multi-drug resistant cavernous tuberculosis control group. Percutaneous lung cavity injection of medicinefor treatment can improve the clinical effectiveness of the multi-drug resistant cavernous tuberculosis significantly. Conclusions It deserves further investigation and spreading in clinical practice.