高毒力肺炎克雷伯杆菌的临床特征和高毒力机制

Clinical features and molecular pathogenesis of hypervirulent Klebsiella pneumoniae

高毒力肺炎克雷伯杆菌是近年发现的具有高侵袭性、高毒力的肺炎克雷伯杆菌，能感染年轻人群导致化脓性肝脓肿、社区获得性肺炎、眼内炎以及其他部位血行播散性感染并可遗留严重后遗症，其中高黏表型和摄铁系统与其高毒力的特性密切相关，文章对近几年的高毒力肺炎克雷伯杆菌的临床特征及高毒力致病机制做总结，希望对以后的临床诊治和研究有帮助。

Rcently, a new hypervirulent and invasive variant of Klebsiella pneumoniae has emerged, whose defining clinical features were the ability to cause primary liver abscess, community-acquired pneumonia, endophthalmitis and metastatically spreading to other tissues with serious sequelae. Its enhanced virulence is closely related to the hypermucoviscous phenotype and the ability to acquire iron more efficiently. The clinical feature and molecular pathogensis of hypervirulent Klebsiella pneumoniae were discussed in this article, which had great significance to clinical treatment and further study.