摘要
目的对白花败酱草Patrinia villosa的化学成分进行研究。方法通过大孔吸附树脂、Sephadex LH-20、反相HPLC等多种色谱方法分离纯化,根据理化性质和波谱数据鉴定化合物结构。结果从白花败酱草干燥全草的70%乙醇提取物中分离得到了14个化合物,分别鉴定为异地芰普内酯(1)、citroside A(2)、grasshopper ketone(3)、(E)-4-hydroxy-3,3,5-trimethy1-4-(3-oxobut-1-en-1-yl)-cyclohexan-1-one(4)、bluemenol A(5)、pubinernoid A(6)、刺槐素(7)、葛根素(8)、5-(1′-hydroxyethyl)-methyl nicotinate(9)、2-[4-(3-hydroxypropyl)-2-methoxyphenoxy]-propane-1,3-diol(10)、1-O-(β-Dglucosyl)-2-[2-methoxy-4-(3-hydroxypropyl)-phenoxy]-propan-3-ol(11)、二氢芥子醇(12)、3,5-dimethoxyl-4-hydroxylphenylpropanol-9-O-β-D-glucopyranoside(13)、2-phenylethyl-α-L-arabinopyranosyl-(1″→6′)-β-D-glucopyranoside(14)。结论所有化合物均为首次从败酱属植物中分离得到。
Objective To study the chemical constituents of Patrinia villosa. Methods Compounds were isolated by a combination of various chromatographic techniques including column chromatography over macroporous resin, Sephadex LH-20, and reversed-phase HPLC. Their structures were elucidated by physiochemical property and spectral analysis. Results Fourteen compounds were isolated and identified as isololiolide(1), citroside A(2), grasshopper kectone(3),(E)-4-Hydroxy-3,3,5-trimethy1-4-(3-oxobut-1-en-1-yl)-cyclohexan-1-one(4), bluemenol A(5), pubinernoid A(6), robinin(7), puerarin(8), 5-(1′-hydroxyethyl)-methyl nicotinate(9), 2-[4-(3-hydroxypropyl)-2-methoxyphenoxy]-propance-1,3-diol(10), 1-O-(β-D-glucosyl)-2-[2-methoxy-4-(3-hydroxypropyl)-phenoxy]-propan-3-ol(11), dihydrosinapyl alcohol(12), 3,5-dimethoxyl-4-hydroxyl-phenylpropanol-9-O-β-D-glucopyranoside(13), and 2-phenylethy-α-L-arabinopyranosyl-(1″→6′)-β-D-glucopyranoside(14). Conclusion All compounds are isolated from the plants of Patrinia Juss. for the first time.
出处
《中草药》
CAS
CSCD
北大核心
2017年第2期247-251,共5页
Chinese Traditional and Herbal Drugs
基金
国家自然科学基金青年基金项目(81303211)
中国博士后科学基金项目(2013M540301)