血管扩张刺激磷蛋白与动脉硬化危险因素的关系研究进展

Research the relationship between vasodilator-stimulated-phosphoprotein and risk factors for atherosclerosis

越来越多的证据表明,c GMP在动脉粥样硬化的发生发展中起着重要作用,血管扩张刺激磷蛋白(vasodilatorstimulated-phosphoprotein,VASP)作为c GMP信号通路的下游底物,是一种肌动蛋白结合蛋白,具有调节细胞黏附、细胞变形、细胞移动、细胞增殖的功能。研究表明,VASP与多种影响动脉粥样硬化(atherosclerosis,AS)的因子有着密切的关系,在AS的发生发展中起着重要作用。文中就VASP和AS危险因素如高血压、高血脂、高血糖的关系进行综述。

In the past few decades, accumulated experimental and clinical evidences suggest that cyclic guanosine monophosphate （cGMP） plays an important role in atheroselerosis. Vasodilator-stimulated phosphoprotein （ VASP）, a major downstream compo- nent of the cGMP signaling cascade, is an actin-binding protein which regulates cell adhesion, morphology change, cell motility and cell proliferation. It has shown that VASP is associated with many factors influencing atherosclerosis, and it plays an important role in the genesis and development of atherosclerosis. The relationships between the occurrence of atherosclerosis and risk factors for atherosclerosis such as hypertension, hyperglycaemia and hyperlipidemia are reviewed in this article.