摘要
小胶质细胞广泛分布于中枢神经系统,是神经系统中发挥免疫功能的主要细胞,生理情况下起监视作用,稳定内环境,小胶质细胞对外界刺激非常敏感,一旦中枢神经系统发生轻微病理变化即可激活小胶质细胞,活化后的小胶质细胞一方面发挥吞噬作用,吞噬细胞碎片,分泌生长因子促进神经修复,另一方面也能分泌一些炎症因子、谷氨酸、一氧化氮等,加重炎症反应,引起继发损伤。文中将对小胶质细胞的特性及其在中枢神经系统疾病中的作用进行综述,为中枢神经系统疾病的治疗提供新靶点。
Microglia are functionally principal immune effector cells widely spread in the central nervous system （CNS） and physiological play a role in monitoring and stabilizing the internal environment. Very sensitive to external stimulation, microglia are eas- ily activated by slight pathological changes in the CNS. The activated microglia, on the one hand, phagocytize cellular debris and ex- crete growth factors to promote nerve repair and, on the other hand, also produce some inflammatory cytokines, glutamate, and nitric oxide, which may aggravate the inflammatory response and lead to secondary injury. This article summarizes the characteristics of microglia and their involvement in CNS diseases and provides a new target for their treatment.
出处
《医学研究生学报》
CAS
北大核心
2017年第2期216-219,共4页
Journal of Medical Postgraduates
基金
云南省科技计划项目-省应用基础研究(昆医联合专项)(2013FB150
2015FA006)
云南省教育厅科学研究项目基金(2014Z062)
昆明医科大学研究生创新基金(2016S26)
关键词
小胶质细胞
中枢神经系统
特性
功能
Microglia
Central nervous system
Characteristics
Function
