生物可降解的聚合物自组装的纳米药物的结构和特征(英文)

Structure and feature of nano-medicines assembled by biodegradable polymers

由生物可降解的聚合物为载体的纳米药物(例如脂质体、微球和微囊)可能有较好的药动学和药效学性质。如果生物可降解聚合物能携带药物穿越生物屏障,显示疾病部位靶向性,生物可降解的聚合物为载体的纳米药物既可监测药物实时分布,又可帮助理解疾病发病和病理。特别在药物化学领域,生物可降解聚合物受到许多研究者关注。本文重点综述了生物可降解聚合物的纳米药物的组装过程、形貌和特征。为了帮助相关领域的读者理解生物可降解聚合物的组装过程和纳米体系的形貌,本文提供了29幅图。这些图使生物可降解聚合物的纳米体系的特征可视化。

Major progress in the understanding of the onset and pathology of a series of diseases highlights the biodegradable polymers based nano-medicine having desirable pharmaceutical and pharmacological property, targeting disease site, crossing biological barriers, exhibiting multiple functions and monitoring real-time drug-distribution. These advantages of nano-medicines attract a great deal of research interests, and the polymeric biodegradable conjugates have been deeply emphasized by medicinal chemistry in particular. In this regard, the present review focuses on the assembling process and feature of biodegradable polymers based nano-medicines. To get insight into the assembling process of the biodegradable polymers and to visualize the feature of the formed nano-species we provided a number of figures.