摘要
目的:评价肾衰方改善CKD4期慢性肾衰患者肾功能及钙磷代谢的临床疗效。方法:选取慢性肾脏病4期(脾肾气虚、瘀血阻滞型)患者60例,随机分为两组:对照组和治疗组,前者给予西医一体化治疗,后者在前者的基础上加用肾衰方,治疗6个月后,观察两组患者临床疗效、中医证候积分、肾功能、24 h尿蛋白定量、钙、磷、1,25(OH)2D3、甲状旁腺、血清FGF-23的变化。结果:治疗后,治疗组临床疗效明显优于对照组(P<0.05),在降低中医证候积分、减少24h尿蛋白定量、降低尿素氮、肌酐、提高肾小球滤过率方面优于对照组(P<0.05)。治疗组在降低血磷、改善继发性甲状旁腺功能亢进方面优于对照组(P<0.05)。结论:肾衰方在治疗脾肾亏虚、瘀血阻滞型CKD4期患者较对照组有明显的临床疗效,能减少蛋白尿、改善肾功能、降低血磷,改善甲状旁腺功能亢进,能延缓慢性肾功能衰竭,具有一定的临床意义。
Objective:To evaluate renal function and calcium phosphate metabolism in patients with CKD4 chronic renal fail- ure. Methods:We selected (spleen and kidney deficiency, blood stasis type) 60 cases of patients with No. 4 chronic kidney disease and divided into 2 groups : control group and treatment group. The former were given the integration treatment of Western Medicine and the latter on the basis of the former used Renal Failure Recipe. After 6 months treatment,we observed changes in two groups' clinical curative effect, TCM syndrome integral, renal function, 24 hours urinary protein quantity, calcium, phosphorus, 1,25 (OH) 2 D3, parathyroid and serum FGF - 23. Results : After treatment, the clinical efficacy of the treatment group was significantly better than the control group ( P 〈 0. 05 ). Compared with the control group ( P 〈 0. 05 ), treatment group' s reduction of TCM syn- drome score, urinary protein in 24 hours, urea nitrogen, creatinine and increasion of glomerular fihration rate were significant. The treatment group was better than the control group(P 〈 0. 05 ) in reducing blood phosphorus and improving parathyroid function. Conclusion:Renal Failure Recipe had obvious clinical curative effect in the treatment of spleen and kidney deficiency and blood stasis type in patients with CKD4 than the control group. It has a certain clinical significance in reducing proteinuria, improving renal function, decreasing serum phosphorus and increasing the parathyroid function. It can delay chronic renal failure.
出处
《辽宁中医杂志》
CAS
北大核心
2017年第2期312-315,共4页
Liaoning Journal of Traditional Chinese Medicine
基金
上海浦东新区中医药事业发展专项项目(PDYNZJ2015-04)
上海市"杏林新星"人才培养(ZY3-RCPY-2-2079)
上海市浦东新区"中医中青年骨干人才培养"项目(PDZYXK-5-2014027)
关键词
肾衰方
慢性肾衰竭
CKD4期
钙磷代谢
Renal Failure Recipe
chronic renal failure
CKIM phase
calcium and phosphorus metabolism