内皮祖细胞在脓毒症中的研究进展

Research Progress of Endothelial Progenitor Cells in Sepsis

内皮祖细胞在血管内皮受损时通过动员、迁移、归巢至受损部位,增殖、分化为内皮细胞并分泌各种细胞因子,促进血管修复及新生。众所周知,血管内皮受损及微循环稳态失调是脓毒症的主要特点。近年来,越来越多的研究发现脓毒症多伴有循环内皮祖细胞数量和功能的变化,而内皮祖细胞数量和功能的变化不仅可用于脓毒症的诊断和预后评估,而且也为脓毒症的干细胞治疗提供了新思路。本文旨在综述内皮祖细胞的内皮修复能力在脓毒症中的研究应用,为脓毒症的干细胞治疗提供新的研究方向。

The endothelial progenitor cells promote vascular repair and neovaseularization through their mobilization, migration and homing to the damaged area, proliferation and differentiation into endothelial cells and secretion of various cytokines when there are damages in vascular endotbeljum. 11 is well known that damages of vascular endotbeliam and steady state maladjustment of microcirculation are the main characteristics of sepsis. Recently, a growing number of studies have found that variations in numbers and function of circulating endothelial progenitor cells are often associated with sepsis, and such variations can not only used for the diagnosis and prognosis evolution of sepsis, but also provide new thoughts in stem cell treatment of sepsis. The paper aims to review the research and application of endothelial repair capacity of endothelial progenitor ceils in sepsis, and provide new research directions of stem cell treatment of sepsis.