硝苯地平对妊娠期高血压的疗效观察

Analysis of the effect and mechanism of Nifedipine on patients with pregnancy induced hypertension

目的:探究硝苯地平对妊娠期高血压患者的疗效及作用机制。方法:选取2014年3月-2015年3月本院接诊的妊娠期高血压患者100例,按照随机数表法分为观察组和对照组各50例。对照组常规治疗,观察组加用硝苯地平治疗,观察两组患者治疗前后平均支脉压(MAP)、24h尿蛋白、总蛋白(TP)、白蛋白(ALB)、舒张压、收缩压、血尿素氮等情况,治疗后不良反应情况及治疗疗效。结果:治疗后,观察组MAP(101.3±8.5mmHg)、24h尿蛋白(1.49±0.26g)水平均小于对照组(113.3±9.5mmHg、2.6±0.4g),TP、ALB水平(62.4±3.1、34.9±3.7g/L)均高于对照组(57.6±3.5、31.6±2.9g/L),舒张压、收缩压(90.73±5.32、132.36±9.47mmHg)、血尿素氮(3.50±0.56mmol/L)均小于对照组(102.32±6.93、146.36±12.36mmHg、4.63±1.02mmol/L),不良反应总发生率(8.0%)低于对照组(28.0%),总有效率(96.0%)优于对照组(82.0%)(均P<0.05)。结论:硝苯地平对妊娠期高血压患者的疗效显著,能够改善患者的病况,改变妊娠结局,有利于胎儿的生长。

Objective： To explore the effect and mechanism of Nifedipine on patients with pregnancy induced hypertension （PIH）. Methods： 100 women with PIH from March 2014 to March 2015 in Affiliated Tongren Hospital were randomly divided into observation group and control group by random number table （50 women in each group）. Women in control group were treated routinely, and women in observation group were added Nifedipine using except for routine treatment. MAP before and after treatment, 24h urinary protein, TP, ALB, diastolic blood pressure, systolic blood pressure, urea nitrogen in blood, adverse reactions, and efficacy of women were compared between two groups. Results ： MAP（101.3 ± 8.5mmHg）, 24h urinary protein（1.49 ± 0.26g） Levels of women in observation group were less than those of women in control group（113.3±9.5mmHg, 2.6±0.4g）. TP（62.4±3.1）and ALB level（34.9±3.7g/L）of women in observation group were significant higher than those of women in control group（57.6±3.5, 31.6±2.9g/L）. Diastolic blood pressure（90.73 ± 5.32 mmHg） and systolic blood pressure （ 132.36 ± 9.47 mmHg）, Blood urea nitrogen （3.50±0.56mmol/L）of women in the observation group were less than those of women in control group（102.32±6.93 mmHg, 146.36±12.36mmHg, 4.63±1.02mmol/L）. Incidence of adverse reactions （8.0%） of women in observation group was less than that of women in control group（28.0%）.The total rate of effective （96.0%） of women in the observation group was better than that of women in the control group（82.0%）. Conclusion： Nifedipine has excellent effect for women with PIH. It can improve the condition of women, increase the outcome of pregnancy, and promote the growth of the fetus.