金天格胶囊联合非甾体镇痛剂治疗膝关节退行性关节炎的临床研究

Clinical research of the treatment of knee osteoarthritis with Jintiange capsule combined with NASIDs

目的观察金天格胶囊联合非甾体抗炎镇静剂对膝关节退行性关节炎的治疗效果,为膝关节退行性关节炎的治疗提供临床依据。方法选取骨科门诊病人膝关节退行性关节炎患者120例,并随机分为3组,每组40人;A组口服金天格胶囊即为骨保护剂组,B组口服洛索洛芬钠片即(glucosamine hydrochloride)为非甾体抗炎镇痛剂组,C组联合口服金天格胶囊及洛索洛芬钠片即为骨保护剂及非甾体镇痛剂组。每组病人均进行为期12 w的治疗,并分别在治疗前、治疗中及治疗后进行临床疗效统计及治疗前后症状改善率比较。结果骨保护剂联合非甾体抗炎镇痛剂组Lequesne指数及治愈率明显高于其他两组,差异有统计学意义(P<0.05);骨保护剂组与非甾体抗炎镇痛剂组差异无统计学意义(P>0.05)。结论单独应用金天格胶囊治疗膝骨性关节炎效果与洛索洛芬钠片相当,金天格胶囊联合洛索洛芬钠片效果优于单独使用金天格胶囊或洛索洛芬钠片,且副反应少,作用持久。

Objective To study the efficacy and the safety of Jintiange capsule combined with non-steroidal anti-inflammatory drugs（ NSAID） in patients with knee osteoarthritis（ OA）,and to provide clinical evidence for the treatment of degenerative OA.Methods One hundred and twenty patients with OA were selected from the orthopedic clinic and divided into 3 groups randomly,with 40 patients in each group. Patients in group A received Jintainge capsule therapy,in group B received the non-steroidal antiinflammatory drugs,and in group C received Jintainge capsule and NSAID. The treatment lasted for 3 months in each group. The clinical efficacy was analyzed before,during,and after the treatment,respectively,and the release of the symptom was compared before and after the treatment. Results The change of Lequene index and the release of clinical symptom were significantly better in group C than in other two groups（ P 〈 0. 05）. There was no significant difference between group A and group B（ P 〉 0. 05）.Conclusion The effect of Jintiange capsules in combination with the NASIDs is better than the efficacy of any of them alone.Moreover,it has long effect duration with little side effect.