氯吡格雷与依达拉奉联合用药对急性脑梗死患者凝血功能和神经功能的影响

Effects of clopidogrel combined with edaravone on blood coagulation and neurological functions in patients with acute cerebral infarction

目的探讨分析氯吡格雷与依达拉奉联合用药对急性脑梗死患者凝血功能和神经功能的影响。方法选择沧州市中心医院2014年9月至2016年9月期间收治的120例急性脑梗死患者为研究对象,采用数字表法分为研究组、对照组各60例。对照组给予氯吡格雷治疗,研究组给予氯吡格雷与依达拉奉联合用药治疗。统计分析2组患者的疗效及凝血、神经功能的改善。结果治疗后2组患者的凝血功能均得到良好的改善,血浆黏度、全血高切黏度、全血低切黏度、纤维蛋白原水平均明显降低,且研究组的改善更明显差异有统计学意义(P<0.05)。经治疗,2组患者的神经功能缺损都得到了明显的改善(P<0.05),研究组的改善情况明显优于对照组差异有统计学意义(P<0.05)。经治疗,研究组60例患者的治疗有效率为91.67%,明显高于对照组的73.33%,差异有统计学意义(P<0.05)。结论氯吡格雷与依达拉奉联合用药治疗急性脑梗死具有确切的临床疗效,能够明显改善急性脑梗死患者的凝血功能,促进神经功能恢复。

Objective To investigate the effects of clopidogrel combined with edaravone on blood coagulation and neurological functions in patients with acute cerebral infarction .Methods One hundred and twenty cases of acute cerebral infarction that were ad-mitted into the hospital from September 2014 to September 2016 were recruited as research subjects and were randomly divided into the study group and the control group , each consisting of 60 cases.The control group was given clopidogrel treatment , while the study group was given clopidogrel combined with edaravone .The therapeutic effects , blood coagulation and neurological functions of the 2 groups were analyzed.Results After treatment, the blood coagulation function of the patients in the two groups were considerably improved , plasma viscosity, whole blood high viscosity, whole blood low viscosity and fibrinogen were all significantly decreased （P〈0.05）, and those of the study group showed better improvement （P〈0.05）.After treatment, neurological deficiency of the 2 groups were more sig-nificantly improved （P〈0.05）, with the improvement of the study group being superior to that of the control group （P〈0.05）.Fol-lowing treatment, the effective rate of the 60 cases in the study group was 91.67%, which was significantly higher than that of the con-trol group （73.33%） （P〈0.05）.Conclusion Clopidogrel combined with edaravone could produce definite effects on acute cerebral infarction, and in the meantime could significantly improve the blood coagulation of the patients with acute cerebral infarction and pro -mote recovery of neurological function as well .