婴儿胆汁淤积性肝病高危因素分析

Analysis of risk factors of infantile cholestatic hepatopathy

目的探讨婴儿胆汁淤积性肝病(infantile cholestatic hepatopathy,ICH)发病的高危因素。方法回顾性分析86例ICH患儿临床资料,同时随机选取100例同期住院患儿临床资料作为对照。统计患儿的性别、发病年龄、喂养史、新生儿期病理性黄疸史、大便颜色、皮肤黄染史、血清丙氨酸转氨酶(alanine transaminase,ALT)、血清总胆汁酸(totalbileacids,TBA)等情况。采用Logistic回归分析确认ICH发病的高危因素。结果 Logistic回归分析结果显示,母乳喂养、新生儿期病理性黄疸史、皮肤和(或)巩膜黄染史、高血清ALT水平为ICH发病的高危因素(P<0.05)。结论母乳喂养、新生儿期病理性黄疸史、皮肤和(或)巩膜黄染史,高血清ALT水平为ICH发病的高危因素,人工喂养为ICH发病的保护因素。

Objective To explore the high risk factors in infantile cholestatic hepatopathy（ICH）.Methods The clinical data of 86 infants with cholestatic hepatopathy were reviewed and analyzed.Meanwhile,100 cases who were hospitalized of the same term were as the control. Children ＇s gender,age,feeding history,history of jaundice in the neonatal period,stool color,skin yellow dye history,serum alanine,transaminase（ ALT）,serum total bile acids（ TBA） were summarize. Logistic regression analysis was been applied to obtain the result. Results The result of logistic regression analysis showed that breast feeding,pathological jaundice in neonatal period,the history of jaundice in skin or sclera and higher level of ALT are the high risk factors for ICH（ P〈0. 05）. Conclusion As the disease causes of ICH,breast feeding,pathological jaundice in neonatal period,the history of jaundice in skin or sclera and higher level of ALT are the high risk factors. While artificial feeding are protective factors.