细辛脑注射液对肺炎新生儿肺表面活性蛋白及氧供状态的影响

Influence of asarone injection for the pulmonary surfactant proteins and oxygen supply state of newborns with pneumonia

目的 观察细辛脑注射液对肺炎新生儿肺表面活性蛋白及氧供状态的影响状况。方法 选取72例肺炎新生儿为研究对象,将其随机分为对照组36例和观察组36例,对照组的新生儿进行常规肺炎治疗,观察组的新生儿则在对照组的基础上加用细辛脑注射液进行治疗,然后将2组新生儿治疗前后的肺表面活性蛋白指标、氧合功能指标及血气分析指标进行分别检测与比较。结果 治疗前2组新生儿的肺表面活性蛋白指标、氧合功能指标及血气分析指标均无显著性差异,而治疗后1、2及5d观察组的肺表面活性蛋白指标、氧合功能指标及血气分析指标均显著地优于对照组（P〈0.05）。结论 细辛脑注射液可显著地改善肺炎新生儿的肺表面活性蛋白及氧供状态,因此在新生儿肺炎的治疗中应用价值较高。

Objective To observe the influence state of asarone injection for the pulmonary surfactant proteins and oxygen supply state of newborns with pneumonia. Methods 72 newborns with pneumonia were selected as the study object, and they were randomly divided into control group （36 cases） and observation group （36 cases）, the control group were treated with conventional treatment of pneumonia, the observation group were treated with asarone injection on the treatment method of control group, then the pulmonary surfactant protein indexes, oxygenation function indexes and blood gas analysis of two groups before and after the treatment were respectively detected and compared. Results The pulmonary surfactant protein indexes, oxygenation function indexes and blood gas analysis of two groups before the treatment all had no significant differences, while the pulmonary surfactant protein indexes, oxygenation function indexes and blood gas analysis of observation group at first, second and fifth day after the treatment were all significantly better than those of control group, all P〈0.05, there were all significant differences. Conclusion The asarone injection can significantly improve the pulmonary surfactant proteins and oxygen supply of newborns with pneumonia, so its application value in the treatment of newborns with pneumonia is higher.