中西医结合治疗甲状腺功能亢进症患者的疗效及对血糖代谢紊乱的影响

Effect of integrated traditional Chinese and western medicine on hyperthyroidism and on blood glucose metabolism disorder

目的 探讨中西医结合治疗甲状腺功能亢进症患者的疗效及对血糖代谢紊乱的影响。方法 选取2014年3月~2016年3月浙江余姚市中医医院收治的70例伴血糖代谢紊乱的甲状腺功能亢进症患者,随机分为2组,各35例,对照组常规予丙硫氧嘧啶治疗,观察组在对照组的基础上结合中医疏肝清热法治疗,治疗前后分别测定血清促甲状腺激素（TSH）、游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）,及空腹血糖（FPG）、餐后2h血糖（2h PG）,观察2组治疗效果及不良反应情况。结果 治疗后,2组TSH、FT3和FT4水平明显改善（P〈0.05）,且观察组FT3、FT4改善明显优于对照组（P〈0.05）;2组FPG、2h PG水平明显降低（P〈0.05）,且观察组明显低于对照组（P〈0.05）;观察组临床总有效率明显高于对照组（P〈0.05）;2组不良反应比较无明显差异。结论 中西医结合治疗甲状腺功能亢进症可显著提升临床疗效,能有效调节血糖代谢,且安全性较高。

Objective To explorer effect of integrated traditional Chinese and western medicine on hyperthyroidism and on blood glucose metabolism disorder. Methods 70 cases of patients with hyperthyroidism during March 2014 to March 2016 were randomly divided into two groups with 35 cases respectively ,and control group were treated with propylthiouracil,while observation group were treated with traditional Chinese medicine on the basis of the control group.Before and after treatment,serum thyroid stimulating hormone（TSH）, triiodothyronine（FT3）, thyroxine（FT4 ） and fasting plasma glucose （FPG） , 2 hours postprandial blood glucose （2hPG） were detected respectively,the curative effect and adverse reactions were observed. Results After treatment,the levels of TSH,FT3 and FT4 of the both two groups were significantly ameliorative （P 〈 0.05）,and FT3 ,FT4 of the observation group were significantly more ameliorative than the control group （P 〈 0.05）.The levels of FPG,2hPG of two groups were significantly depressed （P 〈 0.05）,and those of the observation group were significantly lower than those of the control group （P 〈 0.05）.The clinical effective rate o f the observation group was significantly higher than those of the control group （P 〈 0.05）.Adverse reactions o f two groups were not significantly different. Conclusion The treatment of hyperthyroidism with traditional Chinese and western medicine can significantly improve the clinical curative effect and regulate the blood glucose metabolism, and the safely is high.