克拉霉素联合桂枝茯苓胶囊治疗慢性盆腔炎的疗效及对超敏C反应蛋白的影响

Therapeutic effect of clarithromycin combined with Cassia Twig-Poria Cocos capsule in chronic pelvic inflammatory disease and its influence on highsensitivity C - reactive protein

目的 观察克拉霉素联合桂枝茯苓胶囊治疗慢性盆腔炎的临床疗效以及对超敏C反应蛋白（high sensitive C reactive protein,hsCRP）影响。方法 将106例符合纳入标准的慢性盆腔炎患者,按照入院顺序随机分成观察组和对照组,每组各53例。给予对照组患者克拉霉素缓释胶囊治疗,治疗组在对照组的基础上服用桂枝茯苓胶囊,7~14d为1个疗程,共治疗3个疗程。分别观察2组患者的临床疗效和不良反应发生情况,以及观察2组患者治疗前后的hs-CRP、红细胞沉降率（血沉）、红细胞比容的变化。结果 观察组患者的总有效率为90.57%,对照组为75.47%,观察组的总有效率明显高于对照组（P〈0.05）。2组患者的hs-CRP、血沉和红细胞比容指标在治疗后均明显下降（P〈0.05）,且观察组的hs-CRP、血沉和红细胞比容指标在治疗后均显著低于对照组（P〈0.05）。此外,2组患者的不良反应发生率无明显差异。结论 采用克拉霉素联合桂枝茯苓胶囊治疗慢性盆腔炎可以显著控制炎症反应,临床疗效得到明显提高。

Objective To observe the therapeutic effect of clarithromycin combined with Cassia Twig-Poria Cocos capsule on patients with chronic pelvic inflammatory disease and its influence on high sensitivity C - reactive protein （hs-CRP）. Methods 106 cases o f patients with chronic pelvic inflammatory disease were selected to be divided into the observation group and control group with each group of 53 patients. The patients in con加 1 group were only given clarithromyciii,on the base of control group, patients in observation group were given Cassia Twig-Poria Cocos. Both group were treated for three courses of 7-14 days. Then the therapeutic effect, adverse reactions, hs-CRP, erythrocyte sedimentation rate and hematocrit of patients were investigated. Results The total effective rate o f patients in observation group was 90.57%, and the control group was 75.47%. The total effective rate of observation group was higher than control group with statistically significant difference （^O.OS）. The hs-CRP, erythrocyte sedimentation rate and hematocrit of two groups both decreased after treatment （P〈0.05） and these indexes of observation group was much less than control group （P〈0.05）. Besides, there was no difference of incidence of adverse reactions between two groups during the treatment. Conclusion Treatment of clarithromycin combined with Cassia Twig-Poria Cocos capsule on patients with chronic pelvic inflammatory disease not only can lessen inflammatory reaction, but also can improve the therapeutic effect effectively.