阿司匹林与氯吡格雷联合阿托伐他汀钙治疗急性缺血性脑血管病患者的疗效比较

Clinical comparative of aspirin and clopidogrel combined with atorvastatin calcium in the treatment of acute ischemic cerebrovascular disease

目的 探究阿司匹林与氯吡格雷联合阿托伐他汀钙治疗急性缺血性脑血管病患者的临床疗效。方法 选取海南省人民医院2015年3月~2016年3月收治的27例急性缺血性脑血管病患者,按随机数字表法分为对照组和观察组,对照组13例给予阿司匹林与氯吡格雷治疗,观察组14例对照组基础上给予阿托伐他汀钙治疗,2组均治疗3个月。比较2组治疗后临床疗效,治疗前后NIHSS评分和血脂水平。结果 治疗后,观察组治疗总有效率为92.9%,明显高于对照组53.8%（P〈0.05）;与治疗前比较,2组治疗后NIHSS评分均降低,TC、TG、LDL-C水平均降低,HDL-C均升高（P〈0.05）;与对照组比较,观察组NIHSS评分较低,TC、TG、LDL-C水平较低,HDL-C水平较高（P〈0.05）。结论阿司匹林与氯吡格雷联合阿托伐他汀钙治疗急性缺血性脑血管患者效果显著,能降低患者NIHSS评分,改善血脂水平。

Objective To study the clinical effects of aspirin and clopidogrel combined with atorvastatin calcium in patients with acute ischemic cerebrovascular disease. Methods 27 cases of patients with acute ischemic cerebrovascular disease firom March 2015 to March 2016 in Hainan general hospital were selected,and randomly divided into control group and observation group, 13 patients in the control group,treated with aspirin and clopidogrel,14 eases in the observation group,treat with atorvastatin calcium based on the control group,both two groups were treatment for three months.The total effective rate were compared between the two groups after treatment,NIHSS score and serum lipid level were compared before and after treatment. Results After treatment,the total effective rate of observation group was 92.9%,significantly higher than the control group 53.8% （P〈0.05）.Compared with before treatmeng,the NIHSS score of two groups were decreased,the levels of TC,TG and LDL-C in two groups were decreased,HDL-C was increased （P〈0.05）;Compared with control group,the NIHSS score of observation group was lower,TC,TG and LDL-C were lower,HDL-C was higher （P〈0.05）. Conclusion Aspirin and clopidogrel combined with atorvastatin calcium in treatment with acute ischemic cerebrovascular disease has significant efifect,can reduce the patient＇s NIHSS score,improve blood lipid levels.