血塞通分散片联合利伐沙班对胫骨骨折患者术后关节功能及炎症因子水平的影响

Effects of radix notoginseng saponin dispersible tablets combined with rivaroxaban in treatment of tibial fracture after operation and its effects on joint function and the leves of inflammatory factors

目的探讨血塞通分散片联合利伐沙班对胫骨骨折患者术后关节功能及炎症因子水平的影响。方法选择2014年3月~2016年3月内蒙古民族大学附属医院接诊的90例胫骨骨折患者,均择期进行手术,通过随机数表法分为观察组（n=45）和对照组（n=45）,对照组术后给予血塞通分散片,观察组在对照组基础上给予利伐沙班。治疗2 w后,比较2组血液流变学、炎症因子、关节功能。结果观察组患者肿胀时间、卧床时间与对照组比较均较短（P〈0.05）;治疗后,观察组红细胞压积、全血粘度、纤维蛋白原水平均低于对照组（P〈0.05）;观察组肿瘤坏死因子-α（TNF-α）、白介素-1（IL-1）、IL-6水平均低于对照组（P〈0.05）;观察组治疗后3、6个月,Baird-Jackson评分均高于对照组（P〈0.05）。结论胫骨骨折患者术后应用血塞通分散片联合利伐沙班效果显著,可改善血液流变学,降低炎症因子水平,促进关节功能恢复。

Objective To study curative efficacy of radix notoginseng saponin dispersible tablets combined with rivaroxaban in treatment of tibial fracture after operation and its effects on joint function and the leves of inflammatory factors.Methods 90 patients of tibial fracture who received therapy from March 2014 to March 2016 in our hospital were selected.According to random number table,all elective surgery,those patients were divided into the observation group（n=45） and the control group（n=45）,the control group was treated with radix notoginseng saponin dispersible tablets,while the observation group was treated combined with rivaroxaban.After two weeks of treatment,the hemorheology,inflammatory factors,joint function were compared between two groups.Results The patient swelling time and bed time in the observation group were shorter than the control group（P〈0.05）;after treatment,the levels of red cell volume,whole blood viscosity,fibrinogen in the observation group were lower than the control group（P〈0.05）;the levels of tumor necrosis factor TNF-α,IL-1,IL-6 in the observation group were lower than the control group（P〈0.05）;after treatment three months and six months,the Baird-Jackson scores in the observation group were higher than the control group（P〈0.05）.Conclusion Radix notoginseng saponin dispersible tablets combined with rivaroxaban is well for tibial fracture after operation,which can improve hemorheology,reduce the level of inflammatory factors,promote joint functional recovery.