复方血栓通胶囊治疗青光眼视神经萎缩患者的效果及对眼血流动力学的影响

Application of Fufang Xueshuantong capsule in patients with optic atrophy of glaucoma and its influence on ocular hemodynamics

目的探讨复方血栓通胶囊治疗青光眼视神经萎缩患者的效果及其对眼血流动力学指标的影响。方法选取2014年4月～2016年12月浙江医院收治的124例青光眼视神经萎缩患者,按照入院顺序随机分为实验组与对照组,每组62例。对照组应用神经生长因子＋维生素针的治疗方法,实验组应用神经生长因子＋维生素针＋复方血栓通胶囊治疗方法。观察比较2组患者的临床治疗总有效率、视功能指标（视力、总灰度值）改善情况及眼血流动力学指标（收缩期峰值流速、舒张末期血流速度、阻力指数、搏动指数）的变化情况。结果实验组治疗总有效率为93.55%显著高于对照组治疗总有效率70.97%（P〈0.05）。治疗后,实验组患者的视力显著高于对照组,总灰度值显著低于对照组（P〈0.05）;实验组收缩期峰值流速、舒张末期血流速度显著高于对照组（P〈0.05）,阻力指数、搏动指数低于对照组（P〈0.05）。结论复方血栓通胶囊治疗青光眼视神经萎缩患者效果显著,能够有效改善患者的眼血流动力学指标,改善视力功能。

Objective To analyze the effect of Fufang Xueshuantong capsule on glaucomatous optic atrophy and its influence on ocular hemodynamics.Methods 124 cases of patients with glaucomatous optic atrophy from April 2014 to December 2016 in our hospital were selected,and randomly divided into experimental group and control group according to the order of hospital admission,with 62 cases in each group.The control group was treated with nerve growth factor plus vitamin needling,the experimental group was treated with nerve growth factor and vitamin and compound Xueshuantong capsule.Observation and comparison the total effective rate,visual function（visual acuity,total gray value） improvement of the two groups of patients,as well as the changes of ocular hemodynamic parameters（systolic peak velocity,diastolic End-stage blood flow velocity,resistance index,pulsatility index）.Results The total effective rate of the experimental group was 93.55%（58/62）,the total effective rate of the control group was 70.97%（44/62）,the total effective rate of the experimental group was higher than the control group（P〈0.05））.After treatment,the visual acuity of the experimental group was significantly higher than the control group,the total gray value of the experimental group was significantly lower than the control group（P〈0.05）.The peak systolic velocity and end diastolic velocity in the experimental group were significantly higher than those in the control group（P〈0.05）.The resistance index and pulsatility index in the experimental group were lower than those in the control group（P〈0.05）.Conclusion Compound Xueshuantong capsule is effective in the treatment of glaucomatous optic atrophy,can improve the ocular hemodynamics and improve the visual function.