小金胶囊、逍遥丸联合舒尔经胶囊在乳腺增生患者中的应用及对血管(VEGF、bFGF)的影响

Effects of Xiaojin capsule,Xiaoyao Pill and Shu er jing capsule in patients with hyperplasia of mammary glands and its effects on vascular endothelial growth factor and basic fibroblast growth factor

目的综合分析小金胶囊、逍遥丸联合舒尔经胶囊在乳腺增生患者中的应用及对血管（VEGF、bFGF）的影响。方法选取2013年4月～2016年8月杭州市西溪医院收治的106例乳腺增生患者临床资料作为研究对象,按照入院顺序随机分为实验组与对照组,每组均为53例。对照组应用小金胶囊、逍遥丸治疗方法,实验组应用小金胶囊、逍遥丸联合舒尔经胶囊治疗方法。分析比较2组患者的临床治疗总有效率、不良反应发生率、视觉模拟疼痛评分以及对血管（VEGF、bFGF）水平表达的影响等参数指标。结果实验组临床治疗总有效率为96.23%（51/53）,对照组临床治疗总有效率为86.79%（46/53）,实验组临床治疗总有效率远远高于对照组（P〈0.05）;实验组不良反应发生率为11.32%（6/53）,对照组不良反应发生率为13.21%（7/53）,2组患者不良反应发生率比较无统计学意义;实验组患者视觉模拟疼痛评分为（2.85±0.41）分,对照组患者视觉模拟疼痛评分为（5.25±1.84）分,实验组患者视觉模拟疼痛评分显著低于对照组（P〈0.05）;治疗后,实验组患者在乳腺增生患者中血管（VEGF、bFGF）水平表达下降（P〈0.05）,对照组患者对血管（VEGF、bFGF）水平表达增强。结论小金胶囊、逍遥丸联合舒尔经胶囊在乳腺增生患者中的应用价值比较高,显著降低血管（VEGF、bFGF）表达水平的影响。

Objective To analyze the effects of Xiaogan capsule,Xiaoyao pill combined with Shu er capsule on hyperplasia of mammary gland and its effect on vascular endothelial growth factor（VEGF） and basic fibroblast growth factor（b FGF）.Methods 106 cases of patients with breast hyperplasia treated in our hospital from April 2013 to August 2016 were randomly divided into experimental group and control group according to the order of admission,with 53 cases in each group.The control group was treated with Xiaojin Capsule and Xiaoyao Pills.The experimental group was treated with Xiaojin Capsule,Xiaoyao Pill and Shuerjing Capsule.Analyze the total effective rate of clinical treatment,incidence of adverse reactions,visual analogue pain score and the influence on the expression of VEGF and b FGF in the two groups.Results The total effective rate was 96.23%（51/53） in the experimental group and 86.79%（46/53） in the control group,the total effective rate in the experimental group was much higher than that in the control group（P〈0.05）.The incidence of adverse reactions was 11.32%（6/53） in the experimental group and 13.21%（7/53） in the control group,there was no significant difference in adverse reactions between the two groups.The visual analogue pain score of the experimental group was（2.85±0.41） points,the visual analogue pain score of the control group was（5.25±1.84）,the visual analogue pain score of the experimental group was significantly lower than that of the control group（P〈0.05）.After treatment,the expression of VEGF and b FGF in the patients with hyperplasia of mammary gland decreased,and the levels of VEGF and b FGF in the patients with hyperplasia of mammary glands were significantly higher than those in the untreated group（P〈0.05）,the expression of VEGF and b FGF in the control group was enhanced.Conclusion Xiaojin capsule,Xiaoyao pill and Shu er jing capsule have higher application value in the patients with hyperplasia of mammary gland,and significantly lower the expression of VEGF and b FGF.