肉蔻五味丸治疗精神分裂症患者的临床疗效及对血清SOD、MDA、NO的影响

Clinical efficacy of Roukouwuweiwan in treatment of schizophrenia and its effect on serum SOD,MDA and NO

目的探讨肉蔻五味丸治疗精神分裂症患者的临床疗效及对血清超氧化物歧化酶（SOD）、丙二醛（MDA）、一氧化氮（NO）的影响。方法选取2015年9月~2016年6月宁波市强制医疗所收治的84例精神分裂症患者,随机分为观察组和对照组,每组42例。对照组采用常规方案进行治疗,观察组在对照组基础上加用肉蔻五味丸进行治疗。比较2组患者治疗前后生活质量、血清SOD、MDA、NO水平,分析2组患者临床疗效和不良反应。结果治疗后,观察组总有效率显著高于对照组（P〈0.05）。治疗后,观察组的物质生活、社会功能、心理健康、躯体健康评分均显著高于对照组（P〈0.05）;观察组SOD、MDA、NO水平显著低于对照组（P〈0.05）;观察组的不良反应率显著低于对照组（P〈0.05）。结论精神分裂症患者采取肉蔻五味丸进行治疗,能有效降低患者血清SOD、MDA、NO水平,有利于患者生活质量的提高,临床疗效良好,降低不良反应发生率。

Objective To study the clinical efficacy of Roukouwuwei Wan in the treatment of schizophrenia and its effect on serum superoxide dismutase,malondialdehyde and nitric oxide.Methods 84 cases of patients with schizophrenia were enrolled in our hospital from September 2015 to June 2016,according to coin-casting method divided into observation group and control group,42 cases in each group.The control group was treated with conventional regimen,and the observation group was treated with Rouku Wuwei Pills on the basis of control group.The quality of life,serum SOD,MDA and NO were measured before and after treatment,the clinical efficacy and side effects were analyzed.Results After treatment,the total effective rate of the observation group was significantly higher than the control group（P〈0.05）.After treatment,the scores of physical life,social function,mental health and physical health of the observation group were significantly higher than the control group（P〈0.05）;The levels of superoxide dismutase,malondialdehyde and nitric oxide in the observation group were significantly lower than the control group（P〈0.05）.The adverse reaction rate in the observation group was significantly lower than the control group（P〈0.05）.Conclusion The treatment of schizophrenia patients with Roukouwuwei Wan can reduce the levels of SOD,MDA and NO,improve the quality of life of patients,the clinical efficacy is good and reduce the incidence of adverse reactions.