黄芪注射液对小儿病毒性心肌炎患儿血肌钙蛋白Ⅰ及相关炎性因子水平的影响

Effects of astragalus injection auxiliary on the levels of Serum troponin I and related inflammatory factors inpatients with infantile viral myocarditis

目的探讨黄芪注射液对小儿病毒性心肌炎患儿血肌钙蛋白Ⅰ（troponin I,cTnI）、肌酸激酶同工酶（creatine kinase isoenzyme,CK-MB）、肌酸激酶（creatine kinase,CK）、白介素4（interleukin 4,IL-4）、白介素6（interleukin 6,IL-6）和白介素23（interleukin23,IL-23）水平的影响。方法选取2013年6月～2016年6月浙江衢化医院收治的70例小儿病毒性心肌炎患儿,随机分为对照组和实验组,每组各35例。对照组患儿给予1,6-二磷酸果糖,大量维生素C及极化液等常规治疗,实验组患儿在对照组的基础上给予黄芪注射液。治疗2 w后,比较治疗前后2组患儿血cTnI、CK-MB、CK、IL-4、IL-6,IL-23水平变化,并对比分析2组患儿的临床总有效率。结果与治疗前相比,2组患儿血清cTnI、CK-MB、CK、IL-6及IL-23水平均降低,IL-4水平均升高（P〈0.05）;与对照组相比,实验组患儿血清cTnI、CK-MB、CK、IL-6及IL-23水平较低,IL-4水平较高。实验组临床总有效率较对照组高（P〈0.05）。结论黄芪注射液联合常规治疗小儿病毒性心肌炎更加有效。

Objective To investigate the effects of astragalus injection auxiliary on the levels of serum troponin I（cTnI）,creatine kinase isoenzyme（CK-MB）,creatine kinase（CK）,interleukin 4（IL-4）,interleukin 6（IL-6） and interleukin 23（IL-23） in patients with infantile viral myocarditis.Methods 70 patients with infantile viral myocarditis who were treated in Zhejiang Quzhou Hospital were selected and randomly divided into control group andexperiment group,with35 cases in each group.Patients in control group were treated with 1,6-two-diphosphate fructose,a lot of vitamin C and polarized liquid conventional treatments,patients in experiment group were treated withastragalus injectionon the base of control group.After treatment with two weeks,the serum cTnI,CK-MB,CK,IL-4,IL-6 and IL-23 levels of two groups were compared,and the clinical total effective rate were observed.Results Compared with pre-treatment,the serum cTnI,CK-MB,CK,IL-6 and IL-23 levels of the two groups were decreased,the IL-4 level increased（P〈0.05）.ompared with the control group,the serum cTnI,CK-MB,CK,IL-6and IL-23 levels of experiment group were lower,the IL-4 levelwashigher（P〈0.05）.The clinical total effective rate of experiment group was higher than control group（P〈0.05）.Conclusion Astragalus injectioncombined with conventional therapy aremore effective in treatment with infantile viral myocarditis.